Enzyme catalyzed hydroxymethylation of aromatic aldehydes with formaldehyde. Synthesis of hydroxyacetophenones and (S)-benzoins

Date

2004-07-26

Author

Demir, Ayhan Sıtkı
Ayhan, P
Igdir, AC
Duygu, AN

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Benzaldehyde lyase from the Pseudomonas Fluorescens catalyzed reaction of aromatic aldehydes with formaldehyde providing 2-hydroxy-1-arylethan-1-one in high yields via an acyloin linkage. Kinetic resolution of rac-benzoins with formaldehyde providing (S)-benzoins and 2-hydroxy-1-arylethan-1-one via C-C bond cleavage and a bond formation reaction.

Subject Keywords

Organic Chemistry, Biochemistry, Drug Discovery

URI

https://hdl.handle.net/11511/56111

Journal

TETRAHEDRON

DOI

https://doi.org/10.1016/j.tet.2004.06.015

Collections

Department of Chemistry, Article

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Citation Formats

A. S. Demir, P. Ayhan, A. Igdir, and A. Duygu, “Enzyme catalyzed hydroxymethylation of aromatic aldehydes with formaldehyde. Synthesis of hydroxyacetophenones and (S)-benzoins,” TETRAHEDRON, pp. 6509–6512, 2004, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56111.