Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke

Date

2018-01-01

Author

ÖZÇELİK, AYSUN
ÖNER, TUĞÇE
Demirdogen, Birsen Can
BEK, VEDAT SEMAİ
DEMİRKAYA, ŞEREF
Adalı, Orhan

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Objective: Vitamin D deficiency is known as an important risk factor in pathogenesis of atherosclerosis, which contributes to stroke development. Genetic variations including single nucleotide polymorphisms (SNPs) in enzymes involved in vitamin D metabolism can affect susceptibility to the development of stroke. Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population.

Subject Keywords

Neurology, Clinical Neurology, General Medicine

URI

https://hdl.handle.net/11511/36112

Journal

NEUROLOGICAL RESEARCH

DOI

https://doi.org/10.1080/01616412.2018.1446281

Collections

Department of Biology, Article

Citation Formats

A. ÖZÇELİK, T. ÖNER, B. C. Demirdogen, V. S. BEK, Ş. DEMİRKAYA, and O. Adalı, “Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke,” NEUROLOGICAL RESEARCH, vol. 40, no. 5, pp. 364–371, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36112.