Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke

Date

2018-01-01

Author

ÖZÇELİK, AYSUN
ÖNER, TUĞÇE
Demirdogen, Birsen Can
BEK, VEDAT SEMAİ
DEMİRKAYA, ŞEREF
Adalı, Orhan

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Objective: Vitamin D deficiency is known as an important risk factor in pathogenesis of atherosclerosis, which contributes to stroke development. Genetic variations including single nucleotide polymorphisms (SNPs) in enzymes involved in vitamin D metabolism can affect susceptibility to the development of stroke. Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population.

Subject Keywords

Neurology, Clinical Neurology, General Medicine

URI

https://hdl.handle.net/11511/36112

Collections

Department of Biology, Article