Enantioselective direct aldol reactions promoted by phosphine oxide aziridinyl phosphonate organocatalysts

Date

2015-12-15

Author

Doğan, Özdemir

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A series of phosphine oxide based chiral Lewis bases were screened as organocatalysts for silicon tetrachloride mediated direct asymmetric aldol reactions between cyclohexanone and various aromatic aldehydes. One of the phosphine oxide-aziridinyl phosphonate POAP-A Lewis bases formed the aldol products in up to 75% yield and with 65% ee.

Subject Keywords

Lewis-Base Catalyst, Asymmetric Allylation, Highly Efficient, Aldehydes, Epoxides, Additions, Silicon, Ligand, Binapo

URI

https://hdl.handle.net/11511/36492

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2015.10.013

Collections

Department of Chemistry, Article

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Citation Formats

Ö. Doğan, “Enantioselective direct aldol reactions promoted by phosphine oxide aziridinyl phosphonate organocatalysts,” TETRAHEDRON-ASYMMETRY, pp. 1348–1353, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36492.