Novel Pt(II) complexes containing pyrrole oxime, synthesis, characterization and DNA binding studies

Date

2014-05-05

Author

Altunöz Erdoğan, Deniz
Ozalp-Yaman, Seniz

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Since the discovery of anticancer activity and subsequent clinical success of cisplatin (cis-[PtCl2(NH3)(2)]), platinum-based compounds have since been widely synthesized and studied as potential chemotherapeutic agents. In this sense, three novel nuclease active Pt(II) complexes with general formula; [Pt(NH3)CI(L)] (1), [Pt(L)(2)] (2), and K[PtCl2(L)] (3) in which L is 1-H-pyrrole-2-carbaldehyde oxime were synthesized. Characterization of complexes was performed by elemental analysis, FT-IR, H-1 NMR and mass spectroscopy measurements. Interaction of complexes (1-3) with calf thymus deoxyribonucleic acid (ct-DNA) was investigated by using electrochemical, spectroelectrochemical methods and cleavage studies. The hyperchromic change in the electronic absorption spectrum of the Pt(II) complexes indicates an electrostatic interaction between the complexes and ct-DNA. Binding constant values between 4.42 x 10(3) and 5.09 x 10(3) M-1 and binding side size values between 2 and 3 base pairs were determined from cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies.

Subject Keywords

Inorganic Chemistry, Organic Chemistry, Analytical Chemistry, Spectroscopy

URI

https://hdl.handle.net/11511/37315

Journal

JOURNAL OF MOLECULAR STRUCTURE

DOI

https://doi.org/10.1016/j.molstruc.2014.02.005

Collections

Department of Chemistry, Article

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Citation Formats

D. Altunöz Erdoğan and S. Ozalp-Yaman, “Novel Pt(II) complexes containing pyrrole oxime, synthesis, characterization and DNA binding studies,” JOURNAL OF MOLECULAR STRUCTURE, pp. 50–57, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37315.