Synthesis of calcium carbonate microspheres via inert gas bubbling for orthopedic applications

Date

2020-02-15

Author

Oral, Cagatay M.
Caliskan, Arda
Goctu, Yagmur
KAPUSUZ, DERYA
Ercan, Batur

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

279
views

0
downloads

Calcium carbonate (CaCO3) microspheres consisting of vaterite polymorph have been widely used in biomedical applications. Specifically, vaterite microspheres having hollow cores showed significant potential in drug delivery, however the spontaneous transformation of vaterite to other polymorphs in aqueous environments reduced its controlled in vivo release capability. In this work, calcite and aragonite microspheres having hollow/porous inner cores were synthesized -for the first time-using sodium dodecyl sulfate (SDS) stabilized nitrogen (N-2) bubbles as CaCO3 template in ethylene glycol (EG) solution and water as the precipitation medium. Results demonstrated that porous aragonite microspheres could be synthesized via N-2 gas incorporation, yet for the synthesis of hollow calcite microspheres, N-2 bubbles had be stabilized with SDS to be utilized as CaCO3 templates. The synthesized aragonite and calcite microspheres were found to be stable up to 5 days in Dulbecco's Modified Eagle's Medium (DMEM), and thus would not allow polymorphic transformation in aqueous environments, while promoting proliferation of human bone cells (hFOB) up to 5 days of culture. These findings -for the first time-identified a viable synthesis route for hollow/porous calcite and aragonite microspheres and indicated their promising use in orthopedic applications.

Subject Keywords

Process Chemistry and Technology, Materials Chemistry, Electronic, Optical and Magnetic Materials, Surfaces, Coatings and Films, Ceramics and Composites

URI

https://hdl.handle.net/11511/37440

Journal

CERAMICS INTERNATIONAL

DOI

https://doi.org/10.1016/j.ceramint.2019.10.066

Collections

Department of Metallurgical and Materials Engineering, Article

Suggestions

OpenMETU
Core

Facile control of hydroxyapatite particle morphology by utilization of calcium carbonate templates at room temperature Oral, Çağatay M.; Çalışkan, Arda; Kapusuz, Derya; Ercan, Batur (Elsevier BV, 2020-09-01) Hydroxyapatite (HAp, Ca-10(PO4)(6)(OH)(2)) particles are widely used in orthopedic applications due to their chemical resemblance to the inorganic component of bone tissue. Since physical and chemical properties of HAp particles influence bone regeneration, various synthesis techniques were developed to precisely control the particle properties. However, most of these techniques required high reaction temperatures, which limited the spectrum of obtained HAp particle morphologies. In this study, ellipsoidal,...
Synthesis of calcium carbonate particles for biomedical applications Oral, Çağatay Mert; Ercan, Batur; Department of Metallurgical and Materials Engineering (2020) Calcium carbonate (CaCO3) particles have been widely used in biomedical applications owing to their biocompatibility and biodegradability. In order to effectively utilize CaCO3 particles in biomedical applications, their physical and chemical properties should be systematically controlled. However, this is a challenging task due to the presence of three different anhydrous CaCO3 polymorphs having complex crystallization behavior. In this thesis, CaCO3 particles were synthesized at distinct environments to c...
Fabrication and characterization of porous tricalcium phosphate ceramics Koc, N; Timucin, M; Korkusuz, Feza (Elsevier BV, 2004-01-01) Preforms of beta tricalcium phosphate (beta-TCP) ceramics were produced by using a modified slip casting technique. The slip was prepared by suspending custom-made TCP powder and PMMA beads in an aqueous medium stabilized with an acrylic deflocculant. Porous TCP ceramics were obtained by sintering the polymer-free preforms for 2 h at 1000 degreesC. The XRD pattern for the TCP ceramic indicated that the product was essentially pure beta-TCP. SEM examination of pore size and pore size distribution revealed th...
Characterization by Fourier transform infrared spectroscopy of hydroxyapatite co-doped with zinc and fluoride Uysal, I.; Severcan, F.; Evis, Zafer (Elsevier BV, 2013-09-01) Pure and Zn2+ and/or F- doped hydroxyapatite (HA) were synthesized by the precipitation method and detection of ion incorporations into the HA structure was investigated by a non invasive Fourier transform infrared (FAR) spectroscopic technique. The synthesized materials were sintered at 1100 degrees C for 1 h. The Zn2+ addition amount was kept constant at 2 mol% whereas F- amount was changed. The weight fractions of the HA and CaO were calculated by Rietveld analysis by using GSAS. Co-doping of Zn2+ and F-...
Temperature-Induced Activation of Graphite Co-intercalation Reactions for Glymes and Crown Ethers in Sodium-Ion Batteries Goktas, Mustafa; Akduman, Baris; Huang, Peihua; Balducci, Andrea; Adelhelm, Philipp (American Chemical Society (ACS), 2018-11-29) The intercalation of solvated ions into graphite leads to ternary graphite intercalation compounds (t-GICs). Here, we study the impact of temperature on the electro-chemical activity of graphite electrodes for co-intercalation reactions between 20 and 80 degrees C in sodium cells. For this, a range of linear ethers (mono-, di-, tri-, and tetraglyme) are studied. For the first time, pentaglyme and several crown ethers are also investigated. We find that several solvents that appear as unsuitable for the co-i...

Citation Formats

C. M. Oral, A. Caliskan, Y. Goctu, D. KAPUSUZ, and B. Ercan, “Synthesis of calcium carbonate microspheres via inert gas bubbling for orthopedic applications,” CERAMICS INTERNATIONAL, pp. 3513–3522, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37440.