Synthesis of calcium carbonate particles for biomedical applications

Oral, Çağatay Mert
Calcium carbonate (CaCO3) particles have been widely used in biomedical applications owing to their biocompatibility and biodegradability. In order to effectively utilize CaCO3 particles in biomedical applications, their physical and chemical properties should be systematically controlled. However, this is a challenging task due to the presence of three different anhydrous CaCO3 polymorphs having complex crystallization behavior. In this thesis, CaCO3 particles were synthesized at distinct environments to control their properties. By altering temperature and ethylene glycol concentration of the precursor solutions, vaterite or aragonite content of the particles were maximized, while minimizing the average particle size. In addition, pH and [Ca2+]:[CO32-] ratio of the precursor solutions were adjusted to synthesize vaterite and calcite particles having distinct morphologies. By conducting control experiments, ethylene glycol concentration and solution pH were compared for their influence on CaCO3 particle properties. In order to assess the use of synthesized vaterite, aragonite and calcite particles in orthopedic applications, in vitro experiments were conducted using human bone cells. Moreover, an inert gas bubbling method was used to synthesize hollow CaCO3 microspheres for orthopedic applications. Since requirements for the physical and chemical properties of CaCO3 particles are diverse for each biomedical application, the findings of this thesis contributed to identify viable synthesis routes to obtain CaCO3 particles with distinct properties.


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Citation Formats
Ç. M. Oral, “Synthesis of calcium carbonate particles for biomedical applications,” Thesis (M.S.) -- Graduate School of Natural and Applied Sciences. Metallurgical and Materials Engineering., Middle East Technical University, 2020.