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INFLUENCE OF MEMBRANE-COMPONENTS ON THE STABILITY AND DRUG-RELEASE PROPERTIES OF REVERSE-PHASE EVAPORATION VESICLES (REVS) - LIGHT-SENSITIVE ALL-TRANS RETINAL, NEGATIVELY CHARGED PHOSPHOLIPID DICETYLPHOSPHATE AND CHOLESTEROL
Date
1995-11-01
Author
Gürsel, Mayda
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Incorporation of a negatively charged phospholipid, dicetylphosphate, initially increased encapsulation efficiency (from 12 to 24%) but beyond 5% (molar) a detrimental effect was observed. Rate of drug release from REVs was, for most cases, found to be bi-phasic implying partitioning between the lipid bilayer and the aqueous compartment. It was not possible to prepare liposomes with more than 1% (molar) all-trans retinal (ATR) as a membrane component. When ATR was reduced to 0.5% (molar), encapsulation efficiency increased to 7.76%. Upon exposure to long wave UV (365 nm), release from ATR containing REVs was increased and this was attributed to the formation of 13-cis isomer as indicated by HPLC and UV spectroscopy data.
Subject Keywords
Physical and Theoretical Chemistry
,
Colloid and Surface Chemistry
,
Organic Chemistry
,
Bioengineering
,
Pharmaceutical Science
URI
https://hdl.handle.net/11511/37640
Journal
JOURNAL OF MICROENCAPSULATION
DOI
https://doi.org/10.3109/02652049509006796
Collections
Department of Biology, Article
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M. Gürsel, “INFLUENCE OF MEMBRANE-COMPONENTS ON THE STABILITY AND DRUG-RELEASE PROPERTIES OF REVERSE-PHASE EVAPORATION VESICLES (REVS) - LIGHT-SENSITIVE ALL-TRANS RETINAL, NEGATIVELY CHARGED PHOSPHOLIPID DICETYLPHOSPHATE AND CHOLESTEROL,”
JOURNAL OF MICROENCAPSULATION
, pp. 661–669, 1995, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37640.