INFLUENCE OF MEMBRANE-COMPONENTS ON THE STABILITY AND DRUG-RELEASE PROPERTIES OF REVERSE-PHASE EVAPORATION VESICLES (REVS) - LIGHT-SENSITIVE ALL-TRANS RETINAL, NEGATIVELY CHARGED PHOSPHOLIPID DICETYLPHOSPHATE AND CHOLESTEROL

Date

1995-11-01

Author

Gürsel, Mayda

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Incorporation of a negatively charged phospholipid, dicetylphosphate, initially increased encapsulation efficiency (from 12 to 24%) but beyond 5% (molar) a detrimental effect was observed. Rate of drug release from REVs was, for most cases, found to be bi-phasic implying partitioning between the lipid bilayer and the aqueous compartment. It was not possible to prepare liposomes with more than 1% (molar) all-trans retinal (ATR) as a membrane component. When ATR was reduced to 0.5% (molar), encapsulation efficiency increased to 7.76%. Upon exposure to long wave UV (365 nm), release from ATR containing REVs was increased and this was attributed to the formation of 13-cis isomer as indicated by HPLC and UV spectroscopy data.

Subject Keywords

Physical and Theoretical Chemistry, Colloid and Surface Chemistry, Organic Chemistry, Bioengineering, Pharmaceutical Science

URI

https://hdl.handle.net/11511/37640

Journal

JOURNAL OF MICROENCAPSULATION

DOI

https://doi.org/10.3109/02652049509006796

Collections

Department of Biology, Article

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Citation Formats

M. Gürsel, “INFLUENCE OF MEMBRANE-COMPONENTS ON THE STABILITY AND DRUG-RELEASE PROPERTIES OF REVERSE-PHASE EVAPORATION VESICLES (REVS) - LIGHT-SENSITIVE ALL-TRANS RETINAL, NEGATIVELY CHARGED PHOSPHOLIPID DICETYLPHOSPHATE AND CHOLESTEROL,” JOURNAL OF MICROENCAPSULATION, pp. 661–669, 1995, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37640.