Fabrication and cellular interactions of nanoporous tantalum oxide

Date

2020-10-01

Author

Uslu, Ece
Garipcan, Bora
Ercan, Batur

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

428
views

0
downloads

Tantalum possesses remarkable chemical and mechanical properties, and thus it is considered to be one of the next generation implant materials. However, the biological properties of tantalum remain to be improved for its use in tissue engineering applications. To enhance its cellular interactions, implants made of tantalum could be modified to obtain nanofeatured surfaces via the electrochemical anodization process. In this study, anodization parameters were adjusted to obtain a nanoporous surface morphology on tantalum surfaces and systematically altered to control the pore sizes from 25 to 65 nm using an aqueous HF:H2SO4 electrolyte. Results indicated the formation of Ta2O5‐based nanoporous surface layers, which had up to 28% more surface area and increased nanophase roughness (more than twofolds) compared to nonporous tantalum upon the anodization. It was observed that the nanoporous tantalum oxide surfaces promoted nearly 25% more fibroblast proliferation at 5 days in vitro and 15.5% more cellular spreading. Thus, nanoporous tantalum oxide surfaces can be used to increase biological interactions of the cells and provide a means of improving bioactivity of tantalum for biomaterial applications.

Subject Keywords

Biomaterials, Biomedical Engineering

URI

https://hdl.handle.net/11511/38289

Journal

Journal of Biomedical Materials Research - Part B Applied Biomaterials

DOI

https://doi.org/10.1002/jbm.b.34604

Collections

Department of Metallurgical and Materials Engineering, Article

Suggestions

OpenMETU
Core

Fabrication of functionalized citrus pectin/silk fibroin scaffolds for skin tissue engineering Türkkan, Sibel; Atila, Deniz; Akdağ, Akın; Tezcaner, Ayşen (Wiley, 2018-10-01) In this study, novel porous three-dimensional (3D) scaffolds from silk fibroin (SF) and functionalized (amidated and oxidized) citrus pectin (PEC) were developed for skin tissue engineering applications. Crosslinking was achieved by Schiff's reaction in borax presence as crosslinking coordinating agent and CaCl2 addition. After freeze-drying and methanol treatment, plasma treatment (10 W, 3 min) was applied to remove surface skin layer formed on scaffolds. 3D matrices had high porosity (83%) and interconnec...
Native extracellular matrix/fibroin hydrogels for adipose tissue engineering with enhanced vascularization Kayabolen, Alisan; Keskin, Dilek; Aykan, Andac; Karslioglu, Yildirim; Zor, Fatih; Tezcaner, Ayşen (IOP Publishing, 2017-06-23) Adipose tissue engineering is a promising field for regeneration of soft tissue defects. However, vascularization is needed since nutrients and oxygen cannot reach cells in thick implants by diffusion. Obtaining a biocompatible scaffold with good mechanical properties is another problem. In this study, we aimed to develop thick and vascularized adipose tissue constructs supporting cell viability and adipose tissue regeneration. Hydrogels were prepared by mixing rat decellularized adipose tissue (DAT) and si...
Preparation and characterization of chitosan-gelatin/hydroxyapatite scaffolds for hard tissue engineering approaches Işıklı, Cansel; Hasırcı, Nesrin; Department of Biomedical Engineering (2010) Hard tissue engineering holds the promise of restoring the function of failed hard tissues and involves growing specific cells on extracellular matrix (ECM) to develop „„tissue-like” structures or organoids. Chitosan is a linear amino polysaccharide that can provide a convenient physical and biological environment in tissue regeneration attempt. To improve chitosan‟s mechanical and biological properties, it was blended with another polymer gelatin. 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-...
Implementation and comparison of reconstruction algorithms for magnetic resonance-electric impedance tomography (mr-eit) Martin Lorca, Dario; Eyüboğlu, Behçet Murat; Department of Biomedical Engineering (2007) In magnetic resonance electrical impedance tomography (MR-EIT), crosssectional images of a conductivity distribution are reconstructed. When current is injected to a conductor, it generates a magnetic field, which can be measured by a magnetic resonance imaging (MRI) scanner. MR-EIT reconstruction algorithms can be grouped into two: current density based reconstruction algorithms (Type-I) and magnetic flux density based reconstruction algorithms (Type-II). The aim of this study is to implement a series of r...
Biodegradable polymer promotes osteogenic differentiation in immortalized and primary osteoblast-like cells Onat, Bora; Tuncer, Sinem; Ulusan, Sinem; Banerjee, Sreeparna; Erel Göktepe, İrem (IOP Publishing, 2019-07-01) Biodegradable polymers have been broadly used as agents that can complex with and deliver osteoinductive agents, but osteoinductivity of the polymers themselves has been rarely studied. Here we report the osteoinductivity of poly(4-hydroxy-L-proline ester) (PHPE), a biodegradable cationic polymer with cell penetrating properties. Under physiological conditions, PHPE degrades into trans-4-hydroxy-L-prohne (trans-Hyp), a non-coded amino acid with essential functions in collagen fibril formation and fibril sta...

Citation Formats

E. Uslu, B. Garipcan, and B. Ercan, “Fabrication and cellular interactions of nanoporous tantalum oxide,” Journal of Biomedical Materials Research - Part B Applied Biomaterials, pp. 2743–2753, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/38289.