Hide/Show Apps

Resolution of (±)-2-substituted norbornadiene and hexachloronorbornadiene derivatives using CCL and PLE

2001-09-13
Tanyeli, Cihangir
ÇELİKEL, Gamze
Akhmedov, Idris Mecidolu
(+/-)-2-Hydroxymethylbicyclo[2.2.1]hepta-2,5-diene. (+/-)-2-acetoxymethylbicyclo[2.2.1]hepta-2,5-diene and their hexachlorinated derivatives were resolved via CCL- and PLE-catalysed hydrolysis to afford enantiomerically enriched products with e.e.s of 61-93%. The absolute configurations were determined by transforming 2-hydroxymethylbicyclo[2.2.1]hepta-2,5-diene into the 2-formylbicyclo[2.2.1]hepta-2,5-diene with known absolute configuration.