Resolution of (±)-2-substituted norbornadiene and hexachloronorbornadiene derivatives using CCL and PLE

Tanyeli, Cihangir
Akhmedov, Idris Mecidolu
(+/-)-2-Hydroxymethylbicyclo[2.2.1]hepta-2,5-diene. (+/-)-2-acetoxymethylbicyclo[2.2.1]hepta-2,5-diene and their hexachlorinated derivatives were resolved via CCL- and PLE-catalysed hydrolysis to afford enantiomerically enriched products with e.e.s of 61-93%. The absolute configurations were determined by transforming 2-hydroxymethylbicyclo[2.2.1]hepta-2,5-diene into the 2-formylbicyclo[2.2.1]hepta-2,5-diene with known absolute configuration.
Tetrahedron Asymmetry


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Citation Formats
C. Tanyeli and I. M. Akhmedov, “Resolution of (±)-2-substituted norbornadiene and hexachloronorbornadiene derivatives using CCL and PLE,” Tetrahedron Asymmetry, pp. 2305–2308, 2001, Accessed: 00, 2020. [Online]. Available: