Structural and Biological Analysis of Mesoporous Lanthanum Doped beta TCP For Potential Use as Bone Graft Material

Date

2020-06-01

Author

Motameni, Ali
Dalgıç, Ali Deniz
ALSHEMARY, AMMAR ZEIDAN GHAILAN
Keskin, Dilek
Evis, Zafer

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

195
views

0
downloads

In this study, mesoporous particles of beta-tricalcium phosphate (beta TCP, beta Ca-3(PO4)(2)) and lanthanum (La) doped beta TCP were synthesized using wet precipitation method attached with microwave refluxing system. The obtained materials were characterized and analysed using different sort of techniques such; X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Inductively coupled plasma optical emission spectroscopy (ICP-OES), Brunauer-Emmett-Teller (BET) and helium pycnometer. With incorporation of La3+ ions, relevant expansion in lattice parameters of beta TCP crystal was observed along with inhibition growth rate was observed. beta TCP and La-beta TCP materials were mesoporous in nature, pore diameter and pore volume were expanded with incorporation of La3+ ions. The loading/release on beta TCP and La-beta TCP particles surfaces were evaluated using fetal bovine serum (FBS) proteins. In vitro cell culture studies were performed with human osteosarcoma cell line (Saos-2). The outcomes approved that all La-beta TCP materials were cytocompatible and strict dose dependent effect of La3+ ions was observed on cell viability and alkaline phosphatase (ALP) activity. These results strongly suggest that La-beta TCP materials have a potential application in bone tissue engineering.

Subject Keywords

Materials Chemistry, General Materials Science, Mechanics of Materials

URI

https://hdl.handle.net/11511/40515

Journal

MATERIALS TODAY COMMUNICATIONS

DOI

https://doi.org/10.1016/j.mtcomm.2020.101151

Collections

Department of Engineering Sciences, Article

Suggestions

OpenMETU
Core

Role of boron carbide in carbothermic formation of hexagonal boron nitride Camurlu, H. E.; Sevinc, N.; Topkaya, Yavuz Ali (Springer Science and Business Media LLC, 2006-08-01) Formation of hexagonal boron nitride by carbothermic reduction of boric oxide under nitrogen atmosphere at 1500 degrees C was investigated. Experiments were performed for durations in the range of 15 min to 3 h. Reaction products were subjected to powder X-ray diffraction analysis, chemical analysis and were examined by scanning electron microscope. Formation of hexagonal boron nitride was found to be complete in 3 h with most forming in the initial 2 h. Boron carbide was found to exist in the reaction prod...
Preparation and characterization of zeolite framework stabilized cuprous oxide nanoparticles Zahmakiran, Mehmet; Özkar, Saim (Elsevier BV, 2009-05-15) Zeolite framework stabilized copper(I) oxide nanoparticles (4.8 +/- 2.6 nm) were prepared for the first time by using a four step procedure: the ion exchange of Cu(2+) ions with the extra framework Na(+) ions in Zeolite-Y, the reduction of the Cu(2+) ions within the cavities of zeolite with sodium borohydride in aqueous solution, the dehydration of Zeolite-Y with the copper(0) nanoclusters, and the oxidation of intrazeolite copper(0) nanoclusters by O(2) at room temperature. Zeolite stabilized copper(I) oxi...
Microstructural investigation of Cu2+ doped nanohydroxyapatites Evis, Zafer (Informa UK Limited, 2010-05-01) Pure and Cu2+ doped nanohydroxyapatites were synthesised by a precipitation method to investigate the effect of Cu2+ ions on the structure of hydroxyapatite (HA) and its thermal stability after the air sintering at 1100 degrees C. A small amount of CaO was observed in the Cu2+ doped HAs after the X-ray diffraction results. The addition of Cu2+ changed the hexagonal lattice parameters of the HA and resulted in smaller grain size after sintering at 1100 degrees C. The addition of Cu2+ ions into HA resulted in...
Structural and electrical properties of TlGa(SxSe1-x)(2) mixed crystals KARABULUT, ORHAN; Parlak, Mehmet; Mamedov, G. M. (Elsevier BV, 2007-01-21) Systematic investigations of crystal structure, electrical conductivity and photoconductivity have been carried out on the complete series of TlGa(SxSe1-x)(2) solid solutions. X-ray diffraction (XRD) analyses together with TREOR90 computer program have revealed that this compound shows different structural modifications at each composition. The possible charge transfer mechanisms have been investigated by performing temperature dependent electrical conductivity measurements in the temperature range of 100-4...
Separation of gas and organic/water mixtures by MFI type zeolite membranes synthesized in a flow system Soydas, Belma; Dede, Oezlem; Culfaz, Ali; Kalıpçılar, Halil (Elsevier BV, 2010-01-01) MFI type zeolite membranes were synthesized in a recirculating flow system at 95 degrees C where the synthesis solution was flown over the tubular alpha-alumina supports. The performance of the membranes for the separation of binary gas mixtures and alcohol/water liquid mixtures was investigated. A membrane synthesized by two consecutive synthesis steps had a separation selectivity of 15 and 11 for equimolar mixtures of n-C4H10/CH4 and n-C4H10/N-2 at 200 degrees C, respectively. The membrane selectively per...

Citation Formats

A. Motameni, A. D. Dalgıç, A. Z. G. ALSHEMARY, D. Keskin, and Z. Evis, “Structural and Biological Analysis of Mesoporous Lanthanum Doped beta TCP For Potential Use as Bone Graft Material,” MATERIALS TODAY COMMUNICATIONS, pp. 0–0, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/40515.