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Fam-Ti catalyzed enantioselective alkynylation of aldehydes

2007-08-16
KOYUNCU, Hasan
Doğan, Özdemir
Ferrocenyl-substituted aziridinylmethanol (Fam-1) has been used as a chiral catalyst with titanium for enantioselective alkynylation of aromatic, heteroaromatic, aliphatic, and alpha,beta-unsaturated aldehydes to give the corresponding propargylic alcohols in up to 96% yield and 96% ee. The ligand can be prepared easily and recycled.