A Novel Artificial Pancreas: Energy Efficient Valveless Piezoelectric Actuated Closed-Loop Insulin Pump for T1DM

Download

10.3390:app10155294.pdf

Date

2020-08-01

Author

Kacar, Alp
Özer, Mehmet Bülent
Tascioglu, Yigit

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

182
views

255
downloads

The objective of this work is to develop a closed-loop controlled insulin pump to keep the blood glucose level of Type 1 diabetes mellitus (T1DM) patients in the desired range. In contrast to the existing artificial pancreas systems with syringe pumps, an energy-efficient, valveless piezoelectric pump is designed and simulated with different types of controllers and glucose-insulin models. COMSOL Multiphysics is used for piezoelectric-fluid-structural coupled 3D finite element simulations of the pump. Then, a reduced-order model (ROM) is simulated in MATLAB/Simulink together with optimal and proportional-integral-derivative (PID) controllers and glucose-insulin models of Ackerman, Bergman, and Sorensen. Divergence angle, nozzle/diffuser diameters, lengths, chamber height, excitation voltage, and frequency are optimized with dimensional constraints to achieve a high net flow rate and low power consumption. A prototype is manufactured and experimented with different excitation frequencies. It is shown that the proposed system successfully controls the delivered insulin for all three glucose-insulin models.

Subject Keywords

Piezo-fluid-structural coupled simulation, APS, Valveless micropump, Closed-loop insulin pump

URI

https://hdl.handle.net/11511/40888

Journal

APPLIED SCIENCES-BASEL

DOI

https://doi.org/10.3390/app10155294

Collections

Department of Mechanical Engineering, Article

Suggestions

OpenMETU
Core

A Predictive model for type 2 diabetes mellitus based on genomic and phenotypic risk factors Gül, Hüsamettin; Aydın Son, Yeşim; Department of Health Informatics (2014) Despite the rise in type 2 diabetes (T2D) prevalence worldwide, we do not have a method for early T2D risk prediction. Phenotype variables only contribute to risk prediction near the onset or after the development of T2D. The predictive ability of genetic models has been found to be little or negligible so far. T2D has mostly genetic background but the genetic loci identified so far account for only a small fraction (10%) of the overall heritable risk. In this study, we used data from The Nurses' Health Stu...
Compact Size, and Highly Sensitive, Microwave Sensor for Non-Invasive Measurement of Blood Glucose Level Mohammadi, P.; Mohammadia, A.; Demir, Şimşek; KARA, AYŞEN GÜLÇİN (2021-01-01) None-invasive blood glucose measurement enables effective diagnosis and treatment of diabetic patients. The existing microwave sensors suffer from low sensitivity and large size. This article presents a highly sensitive and compact size non-invasive microwave sensor for real-time blood glucose measurements. We have developed a new sensing technique using directly connected Branch Line Coupler and Split Ring Resonators. This technique significantly improves the sensitivity by mitigating the limited coupling ...
A non-conventional TD-NMR approach to monitor honey crystallization and melting Berk, Berkay; Grunin, Leonid; Öztop, Halil Mecit (Elsevier BV, 2021-03-01) Crystallization of glucose is a natural process that could occur in honey due to several reasons and glucose is one of them. In this study, a non-conventional TD-NMR pulse sequence, Magic Sandwich Echo (MSE), was used to monitor the crystallization of honey at 14 °C. Honey samples were seeded with glucose to induce crystallization. T1 and T2 relaxation times were also measured during 96 h of storage. Mono-exponential and bi-exponential relations were used to explain T1 and T2, respectively. As a complementa...
Nanometer-Thick Mn:NiO and Co:NiO Films for High Performance Nonenzymatic Biosensors Tunca, Sensu; Tutel, Yusuf; Koylan, Serkan; Ünalan, Hüsnü Emrah (2021-01-01) People with diabetes require regular blood sugar level monitoring, using commercial enzyme-based biosensors. There is a considerable need to develop biosensors with nonenzymatic electrodes to eliminate the drawbacks of enzymes. Nanostructured nickel oxide (NiO) thin films are highly promising materials for the development of nonenzymatic glucose and hydrogen peroxide (H2O2) biosensors. Although the biosensor performance can be easily attained with nonenzymatic electrodes, their commercialization still requi...
MATERNAL OBESITY EFFECT ON OFFSPRING PANCREATIC ENDOCRINE CELLS: INVESTIGATION OF THE CELL TRANSDIFFERENTIATION PROFILE THAT CAUSES DIABETIC SUSCEPTIBILITY FEYAT, MEHMET SEDAT; Yanık, Tülin; Özçubukçu, Salih; Department of Biotechnology (2022-6-13) In general, Type 2 Diabetes (T2D) is a disease characterized by impaired functioning of pancreatic beta cells and progressive insulin hormone deficiency progressively in combination with physiologically ongoing insulin resistance. In the later stages of the disease, beta cell dysfunction is defined as beta cell death and a decrease in functional cell count. It is a common clinical finding in patients with T2D that therapeutic drugs lowering insulin resistance and diet in the course of the disease treatment ...

Citation Formats

A. Kacar, M. B. Özer, and Y. Tascioglu, “A Novel Artificial Pancreas: Energy Efficient Valveless Piezoelectric Actuated Closed-Loop Insulin Pump for T1DM,” APPLIED SCIENCES-BASEL, pp. 0–0, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/40888.