Multifunctional layer-by-layer modified chitosan/poly(ethylene glycol) hydrogels

Date

2019-03-01

Author

Onat, Bora
Ulusan, Sinem
Banerjee, Sreeparna
Erel Göktepe, İrem

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We report the surface modification of chitosan/poly(ethylene glycol) (chitosan/PEG) hydrogel materials via layer-by-layer (LbL) technique using stimuli-responsive polymers. Water-soluble complexes of Tannic Acid (TA) and a broad-spectrum antibiotic, Ciprofloxacin (Cipro) were prepared and co-assembled at the surface of Chitosan/PEG hydrogels with poly(N-vinyl caprolactam) (PVCL). Compared to the bare hydrogels, the surface spreading and proliferation of human fibroblasts were significantly enhanced on precast hydrogels coated with TA-Cipro/PVCL multilayers. LbL coating also provided enhanced Cipro release from the hydrogel surface at 37 degrees C compared to bare hydrogels. TA-Cipro/PVCL coated hydrogels showed antibacterial activity through chitosan and temperature-induced release of Cipro from multilayers. Chitosan and Cipro showed a coordinated antibacterial effect on Eschericia coli and Bacillus cereus, reducing their minimum inhibitory concentration (MIC). This effect was more pronounced on B. cereus. LbL modification of chitosan-based hydrogels using stimuli responsive polymers can be advantageous for bringing multiple functionalities to these materials without sacrificing their intrinsic properties such as antibacterial activity and biocompatibility. Such LbL-coated hydrogels hold promise in wound treatment as they may promote fibroblast proliferation and skin tissue regeneration.

Subject Keywords

Organic Chemistry, General Physics and Astronomy, Polymers and Plastics

URI

https://hdl.handle.net/11511/42203

Journal

EUROPEAN POLYMER JOURNAL

DOI

https://doi.org/10.1016/j.eurpolymj.2018.12.028

Collections

Department of Chemistry, Article

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Citation Formats

B. Onat, S. Ulusan, S. Banerjee, and İ. Erel Göktepe, “Multifunctional layer-by-layer modified chitosan/poly(ethylene glycol) hydrogels,” EUROPEAN POLYMER JOURNAL, pp. 73–86, 2019, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/42203.