Copper-catalyzed asymmetric conjugate addition of diethylzinc to substituted chalcones using a chiral phosphine ligand

Date

2011-09-15

Author

Doğan, Özdemir
Bulut, Adnan
Polat, Savas
Tecimer, M. Ali

Metadata

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

A series of chiral phosphine PFAM and phosphine oxide POFAM ligands were studied for the copper-catalyzed asymmetric diethylzinc addition to enones. One of these ligands, PFAM2, was an efficient catalyst with a variety of enones to give conjugate addition products in up to 96% yield and 92% ee. (C) 2011 Elsevier Ltd. All rights reserved.

URI

https://hdl.handle.net/11511/41784

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2011.09.003

Collections

Department of Chemistry, Article