A smartphone based surface plasmon resonance imaging (SPRi) platform for on-site biodetection

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Date

2017-02-01

Author

Güner, Havva Gizem
Kokturk, Guzin
Celik, Mehmet
Esen, Elif
Topal, Ahmet E.
Ayas, Sencer
Uludag, Yildiz
ELBÜKEN, ÇAĞLAR
DANA, Aykutlu

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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We demonstrate a surface plasmon resonance imaging platform integrated with a smartphone to be used in the field with high-throughput biodetection. Inexpensive and disposable SPR substrates are produced by metal coating of commercial Blu-ray discs. A compact imaging apparatus is fabricated using a 3D printer which allows taking SPR measurements from more than 20.000 individual pixels. Real-time bulk refractive index change measurements yield noise equivalent refractive index changes as low as 4.12 x 10(-5) RIU which is comparable with the detection performance of commercial instruments. As a demonstration of a biological assay, we have shown capture of mouse IgG antibodies by immobilized layer of rabbit anti-mouse (RAM) IgG antibody with nanomolar level limit of detection. Our approach in miniaturization of SPR biosensing in a cost-effective manner could enable realization of portable SPR measurement systems and kits for point-of-care applications. (C) 2016 Published by Elsevier B.V.

Subject Keywords

Optical sensor, Biosensors, Mobile sensing, Optical discs, Surface plasmon resonance imaging, Plasmonics

URI

https://hdl.handle.net/11511/41865

Journal

SENSORS AND ACTUATORS B-CHEMICAL

DOI

https://doi.org/10.1016/j.snb.2016.08.061

Collections

Department of Architecture, Article

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Citation Formats

H. G. Güner et al., “A smartphone based surface plasmon resonance imaging (SPRi) platform for on-site biodetection,” SENSORS AND ACTUATORS B-CHEMICAL, pp. 571–577, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/41865.