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Enzyme Catalyzed Trans-Benzoin Condensation
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Date
2018-04-01
Author
BİLİR, Gökçil
AYHAN SITKI, Demir
Özçubukçu, Salih
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Benzaldehyde lyase (BAL) is an enzyme that is used in the C-C bond cleavage and formation which was isolated first from Pseudomonas fluorescens Biovar I. It requires thiamine diphosphate (ThDP) and Mg(II) ions as cofactors. In this work, BAL was used as an enzymatic catalysis for the trans-benzoin condensation reaction between racemic benzoins and benzyloxyacetaldehyde to form unsymmetrical benzoin products with moderate enantiomeric excesses. (S)-benzoin derivatives remained unreacted at the end of the reaction. In this enzymatic trans-benzoin condensation, benzyloxyacetaldeyhde acted as acceptor and different variety of racemic benzoin derivatives were used as donor and (R)-2-hydroxy-1-phenylpropanone derivatives were synthesized up to 66% ee.
Subject Keywords
Benzaldehyde lyase
,
Benzoin condensation
,
Enzymatic asymmetric catalysis
URI
https://hdl.handle.net/11511/41941
Journal
Journal of the Turkish Chemical Society, Section A: Chemistry
DOI
https://doi.org/10.18596/jotcsa.414603
Collections
Department of Chemistry, Article