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Efficient synthesis of ferrocenylenones by Friedel-Crafts acylation with EtAlCl2-Me3Al

2005-01-17
Doğan, Özdemir
SENOL, VOLKAN
ZEYTİNCİ, SERHAT
KOYUNCU, HASAN
BULUT, ADNAN
Efficient synthesis of ferrocenyl en ones using a Friedel-Crafts acylation reaction is described. Acryloyl, methacryloyl, crotonoyl, cinnamoyl, and beta-methylcrotonoyl chlorides react with ferrocene in the presence of a Lewis acid (EtAlC2 or EtAlCl2-Me3Al) to give the corresponding ferrocenyl en ones (acryloyl, methacryloyl, crotonoyl, cinnamoyl, and methylcrotonoylferrocenes) in good isolated yields. Besides ferrocenylenones, chloroactylferrocene is also synthesised by this method.