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Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes

Ozalp, V. Cengiz
Cam, Dilek
Hernandez, Frank J.
Hernandez, Luiza I.
Schafer, Thomas
Öktem, Hüseyin Avni
A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 mu M up to 2 mM.