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Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings

Gungor, Bilgi
Yagci, Fuat Cem
Gürsel, Mayda
Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon alpha (IFN alpha) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity.