Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings

Gungor, Bilgi
Yagci, Fuat Cem
Gürsel, Mayda
Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon alpha (IFN alpha) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity.


Differential immune activation following encapsulation of immunostimulatory CpG oligodeoxynucleotide in nanoliposomes.
Erikçi, E; Gürsel, Mayda; Gürsel, I (2011-02-01)
The immunogenicity of a vaccine formulation is closely related to the effective internalization by the innate immune cells that provide prolonged and simultaneous delivery of antigen and adjuvant to relevant antigen presenting cells. Endosome associated TLR9 recognizes microbial unmethylated CpG DNA. Clinical applications of TLR9 ligands are significantly hampered due to their pre-mature in vivo digestion and rapid clearance. Liposome encapsulation is a powerful tool to increase in vivo stability as well as...
Design and characterization of capsaicin loaded nanoemulsions
Akbaş, Elif; Öztop, Halil Mecit; Söyler, Ulviye Betül; Department of Food Engineering (2016)
In recent years, nanoemulsion based systems have been successfully used in food, medical and pharmaceutical applications as effective lipophilic carrier systems for nutraceuticals, drugs, antioxidants and antimicrobial agents. The primary active ingredient of chili pepper, capsaicin is a hydrophobic substance and was proved to be a compound showing good antimicrobial activity against various microorganisms. The aim of the proposed study was to prepare and characterize capsaicin loaded nanoemulsion systems. ...
Liposomes as immunological adjuvants and vaccine carriers
Gregoriadis, G; Gursel, I; Gürsel, Mayda; McCormack, B (1996-08-01)
Work by numerous laboratories in the last two decades has shown that liposomes promote humoral and cell-mediated immunity to a large variety of bacterial, protozoan, viral and tumour cell antigens. This immunoadjuvant action of liposomes depends on their structural characteristics which control vesicle fate in vivo including the mode of antigen interaction with antigen-presenting cells. Liposomal adjuvanticity is further promoted by receptor mediated targeting to macrophages or the presence of co-adjuvants ...
CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes.
Sugiyama, T; Gürsel, Mayda; Takeshita, F; Coban, C; Conover, J; Kaisho, T; Akira, S; Klinman, DM; Ishii, KJ (The American Association of Immunologists, 2005-02-15)
Synthetic immunostimulatory nucleic acids such as CpG DNA are being harnessed therapeutically as vaccine adjuvants, anticancer or antiallergic agents. Efforts to identify nucleic acid-based agents capable of more specifically modulating the immune system are being developed. The current study identifies a novel class of single-stranded oligoribonucleotides (ORN) containing unmethylated CpG motifs and a poly(G) run at the 3 end (CpG ORN) that directly stimulate human CD14 CD11c monocytes but not dendritic ...
Bioactive agent carrying PLGA nanoparticles in the treatment of skin diseases
Küçükturhan, Aysu; Hasırcı, Nesrin; Hasırcı, Vasıf Nejat; Department of Biomedical Engineering (2012)
The aim of this study was to develop drug delivery system based on poly(lactic acid-co-glycolic acid) (PLGA) nanoparticles (NPs) to achieve personalized treatment of selected skin disorders, like photo-aging, psoriasis and atopic dermatitis. Dead Sea Water (DSW) and Retinyl Palmitate (RP) were used as active agents and they were loaded in PLGA NPs prepared either as spheres or capsules by o/w or w/o/w methods. MgCl2 and bovine serum albumin (BSA) served as model active compounds. The diameter of the NPs was...
Citation Formats
B. Gungor, F. C. Yagci, İ. GÜRSEL, and M. Gürsel, “Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings,” ONCOIMMUNOLOGY, pp. 0–0, 2014, Accessed: 00, 2020. [Online]. Available: