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Voltammetric methods of reboxetine analysis and the mechanism of its electrode reactions
Date
2013-05-01
Author
Altunöz Erdoğan, Deniz
Erk, Nevin
Kilic, Esma
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Reboxetine (RBX) electrochemical redox behavior at hanging mercury drop (HMDE) and glassy carbon electrodes (GCE) was studied in various pH Britton-Robinson universal buffers using cyclic voltammetry and square-wave voltammetry. RBX was reduced at the HMDE and oxidized at the GCE with reversible adsorption controlled and irreversible diffusion controlled processes respectively. The anodic peak is due to the amine and the cathodic peak may correspond to oxygen protonation. An oxidation reaction mechanism is proposed. The linear relation between peak currents and RBX concentration allowed simple, sensitive, precise and inexpensive voltammetric procedures to be developed. The limit of detection was 0.04 A mu M RBX. The procedures were successfully applied to human urine and RBX tablet assay. Therapeutic RBX concentrations in human serum were not detected due to strong drug-protein binding. Using bovine serum albumin, the methods were used to investigate the effect of serum protein binding on RBX determination.
Subject Keywords
Materials Chemistry
,
General Chemistry
URI
https://hdl.handle.net/11511/45634
Journal
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
DOI
https://doi.org/10.2478/s11532-013-0213-8
Collections
Department of Chemistry, Article
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D. Altunöz Erdoğan, N. Erk, and E. Kilic, “Voltammetric methods of reboxetine analysis and the mechanism of its electrode reactions,”
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
, pp. 706–716, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/45634.