Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Esiyok, Peruze Ayhan
Seven, Ozlem
Eymur, Guluzar
Tatar, Gamze Bora
Demir, Ayhan Sıtkı
New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.


SEN, S; CELEBI, N; TURKER, L; Önal, Ahmet Muhtar (Wiley, 1993-09-01)
Anodic oxidation peak potentials (E(p,a)) of some fluorene derivatives were measured on a Pt-degrees electrode versus Ag-degrees/Ag+ in acetonitrile-TBAFB by cyclic voltammetry. The highest occupied molecular orbital (HOMO) energies of the compounds were calculated within the Huckel molecular orbital (HMO) framework. The measured E(p,a) values were correlated to theoretical HOMO energies with a linear regression model.
Proquinoidal-Conjugated Polymer as an Effective Strategy for the Enhancement of Electrical Conductivity and Thermoelectric Properties
Tam, Teck Lip Dexter; Ng, Chee Koon; Lim, Siew Lay; Yıldırım, Erol; Ko, Jieun; Leong, Wei Lin; Yang, Shuo-Wang; Xu, Jianwei (American Chemical Society (ACS), 2019-10-22)
P-doping of conjugated polymers requires electron transfer from the conjugated polymer to the p-dopant. This implies that the highest occupied molecular orbital (HOMO) of the conjugated polymer has to be higher than the lowest unoccupied molecular orbital (LUMO) of the p-dopant. Although commonly used p-dopants such as 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ) have a low LUMO of -5.24 eV, most conjugated polymers used in high-performance field-effect transistors are donor- acceptor-type ...
Voltammetric methods of reboxetine analysis and the mechanism of its electrode reactions
Altunöz Erdoğan, Deniz; Erk, Nevin; Kilic, Esma (Walter de Gruyter GmbH, 2013-05-01)
Reboxetine (RBX) electrochemical redox behavior at hanging mercury drop (HMDE) and glassy carbon electrodes (GCE) was studied in various pH Britton-Robinson universal buffers using cyclic voltammetry and square-wave voltammetry. RBX was reduced at the HMDE and oxidized at the GCE with reversible adsorption controlled and irreversible diffusion controlled processes respectively. The anodic peak is due to the amine and the cathodic peak may correspond to oxygen protonation. An oxidation reaction mechanism is ...
Phase transition of chemically synthesized FePt nanoparticles under high pressure
ŞİMŞEK, TELEM; Karci, Ozgur; ÖZCAN, ŞADAN (The Scientific and Technological Research Council of Turkey, 2018-01-01)
We present the results of a study related to phase transformation of chemically synthesized FePt nanoparticles under high pressure from face-centered cubic into face-centered tetragonal structure. As-synthesized nanoparticles are around 4.5 nm and show superparamagnetic behavior at 300 K. After annealing under 60 bar pressure of hydrogen at 400 degrees C for 2 h, nanoparticles exhibit strong ferromagnetic behavior with 5391 Oe coercivity. Results show that high-pressure annealing lowers the decomposition te...
Novel Molecular Building Blocks Based on the Boradiazaindacene Chromophore: Applications in Fluorescent Metallosupramolecular Coordination Polymers
Bozdemir, Oe. Altan; Buyukcakir, Onur; AKKAYA, Engin Umut (Wiley, 2009-01-01)
We designed and synthesized novel boradiazaindacene (Bodipy) derivatives that are appropriately functionalized for metal-ion-mediated supramolecular polymerization. Thus, ligands for 2-terpyridyl-, 2,6-terpyridyl-. and bipyridyl-functionalized Bodipy dyes were synthesized through Sonogashira couplings. These fluorescent building blocks are responsive to metal ions in a stoichiometry-dependent manner. Octahedral coordinating metal ions such as Zn-II result in polymerization at a stoichiometry corresponding t...
Citation Formats
P. A. Esiyok et al., “Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies,” TURKISH JOURNAL OF CHEMISTRY, pp. 338–344, 2014, Accessed: 00, 2020. [Online]. Available: