Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Date

2014-01-01

Author

Esiyok, Peruze Ayhan
Seven, Ozlem
Eymur, Guluzar
Tatar, Gamze Bora
DAYANGAÇ ERDEN, DİDEM
YELEKÇİ, Kemal
YURTER, HAYAT
Demir, Ayhan Sıtkı

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New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.

Subject Keywords

General Chemistry

URI

https://hdl.handle.net/11511/56814

Journal

TURKISH JOURNAL OF CHEMISTRY

DOI

https://doi.org/10.3906/kim-1305-56

Collections

Department of Chemistry, Article

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Citation Formats

P. A. Esiyok et al., “Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies,” TURKISH JOURNAL OF CHEMISTRY, pp. 338–344, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56814.