Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

2014-01-01
Esiyok, Peruze Ayhan
Seven, Ozlem
Eymur, Guluzar
Tatar, Gamze Bora
DAYANGAÇ ERDEN, DİDEM
YELEKÇİ, Kemal
YURTER, HAYAT
Demir, Ayhan Sıtkı
New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.
TURKISH JOURNAL OF CHEMISTRY

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Citation Formats
P. A. Esiyok et al., “Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies,” TURKISH JOURNAL OF CHEMISTRY, pp. 338–344, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56814.