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Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies
Date
2014-01-01
Author
Esiyok, Peruze Ayhan
Seven, Ozlem
Eymur, Guluzar
Tatar, Gamze Bora
DAYANGAÇ ERDEN, DİDEM
YELEKÇİ, Kemal
YURTER, HAYAT
Demir, Ayhan Sıtkı
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New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.
Subject Keywords
General Chemistry
URI
https://hdl.handle.net/11511/56814
Journal
TURKISH JOURNAL OF CHEMISTRY
DOI
https://doi.org/10.3906/kim-1305-56
Collections
Department of Chemistry, Article
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P. A. Esiyok et al., “Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies,”
TURKISH JOURNAL OF CHEMISTRY
, pp. 338–344, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56814.