A Novel DAD Type and Folic Acid Conjugated Fluorescent Monomer as a Targeting Probe for Imaging of Folate Receptor Overexpressed Cells

Kanik, Fulya Ekiz
Ag, Didem
Seleci, Muharrem
Barlas, Firat Baris
Kesik, Melis
Hizalan, Gonul
Akpinar, Hava
Toppare, Levent Kamil
We describe a modification and post-functionalization technique for a donor-acceptor-donor type monomer; 6-(4,7-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-2H-benzo[d][1,2,3]triazol-2-yl)hexan-1-amine. Folic acid was attached to the fluorescent structure. The conjugation was confirmed via NMR and Fourier transform infrared analyses. Cytotoxicity was investigated and the comparison of association of targeted monomeric structures in tumor cells was monitored via fluorescence microscopy. (C) 2014 American Institute of Chemical Engineers


A Diverse-Stimuli Responsive Chemiluminescent Probe with Luminol Scaffold and Its Electropolymerization
Asil Alptekin, Demet; Algi, Fatih; Önal, Ahmet Muhtar (Wiley, 2010-10-01)
A diverse-stimuli responsive chemiluminescent system, SNS-Lum, and its electropolymerization to give PSNS-Lum, which is the first example of conjugated polymers with pendant luminol arms inducing chemiluminescence in the presence of super oxide radical anion under neutral conditions, are highlighted.
YOSHIOKA, T; SKALKO, N; Gürsel, Mayda; GREGORIADIS, G; FLORENCE, AT (Informa UK Limited, 1995-01-01)
An aqueous dispersion of niosomes (non-ionic surfactant vesicles) emulsified in an external oil phase forms the vesicle-in-water-in-oil (v/w/o) system described in this paper. The properties of the surfactant used to form the vesicles, the surfactant or surfactant mixture used to stabilize the emulsion and the nature of the oil phase can be changed to provide systems of different capacities for drug or antigen and different release characteristics. The same nonionic surfactant is used as the principle amphi...
A method for wafer level hermetic packaging of SOI-MEMS devices with embedded vertical feedthroughs using advanced MEMS process
Torunbalci, Mustafa Mert; Alper, Said Emre; Akın, Tayfun (IOP Publishing, 2015-12-01)
This paper presents a novel, inherently simple, and low-cost fabrication and hermetic packaging method developed for SOI-MEMS devices, where a single SOI wafer is used for the fabrication of MEMS structures as well as vertical feedthroughs, while a single glass cap wafer is used for hermetic encapsulation and routing metallization. Hermetic encapsulation can be achieved either with the silicon-glass anodic or Au-Si eutectic bonding techniques. The dies sealed with anodic and Au-Si eutectic bonding provide a...
A ferrocene functionalized multichromic p and n dopable donor-acceptor-donor type conjugated polymer
Ozdemir, Serife; BALAN, Abidin; BARAN, Derya; Doğan, Özdemir; Toppare, Levent Kamil (Elsevier BV, 2010-10-01)
Ferrocene substituted donor-acceptor-donor type polymer; poly(5,8-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-2-(naphthalen-2-yl)-3-ferrocenyl-4a,8a-dihydroquinoxaline) (PDEFNQ) was synthesized and its electrochromic properties were investigated. Cyclic voltammetry and spectroelectrochemistry studies for PDEFNQ showed that it is a multichromic green to transmissive polymer with high tendency to be both p and n doped. PDEFNQ is foreseen as a promising candidate for various applications.
A novel multi-electrochromic polymer based on selenophene and benzotriazole via electrochemical and chemical polymerization
Demir, Fatma; Keles, Duygu; Karabag, Aliekber; Çırpan, Ali; Toppare, Levent Kamil (Informa UK Limited, 2019-03-04)
In this study, a novel donor-acceptor type monomer was designed based on selenophene and benzotriazole with a bulky pendant group and synthesized through Stille coupling reaction. The monomer was polymerized electrochemically by using cyclic voltammetry and also chemically by oxidation in the presence of FeCl3. Both polymers were then compared in terms of their optical properties, electrochemical and spectroelectrochemical behaviors, kinetic and colorimetric properties and surface morphologies. Independent ...
Citation Formats
F. E. Kanik et al., “A Novel DAD Type and Folic Acid Conjugated Fluorescent Monomer as a Targeting Probe for Imaging of Folate Receptor Overexpressed Cells,” BIOTECHNOLOGY PROGRESS, pp. 952–959, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/45933.