A Novel DAD Type and Folic Acid Conjugated Fluorescent Monomer as a Targeting Probe for Imaging of Folate Receptor Overexpressed Cells

Date

2014-07-01

Author

Kanik, Fulya Ekiz
Ag, Didem
Seleci, Muharrem
Barlas, Firat Baris
Kesik, Melis
Hizalan, Gonul
Akpinar, Hava
TİMUR, SUNA
Toppare, Levent Kamil

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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We describe a modification and post-functionalization technique for a donor-acceptor-donor type monomer; 6-(4,7-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-2H-benzo[d][1,2,3]triazol-2-yl)hexan-1-amine. Folic acid was attached to the fluorescent structure. The conjugation was confirmed via NMR and Fourier transform infrared analyses. Cytotoxicity was investigated and the comparison of association of targeted monomeric structures in tumor cells was monitored via fluorescence microscopy. (C) 2014 American Institute of Chemical Engineers

Subject Keywords

Fluorescence microscopy, Cell imaging, Folic acid, Conjugation

URI

https://hdl.handle.net/11511/45933

Collections

Department of Chemistry, Article