Micelles As Delivery System for Cancer Treatment

Micelles are nanoparticles formed by the self-assembly of amphiphilic block copolymers in certain solvents above concentrations called critical micelle concentration (CMC). Micelles are used in different fields like food, cosmetics, medicine, etc. These nanosized delivery systems are under spotlight in the recent years with new achievements in terms of their in vivo stability, ability to protect entrapped drug, release kinetics, ease of cellular penetration and thereby increased therapeutic efficacy. Drug loaded micelles can be prepared by dialysis, oil-in-water method, solid dispersion, freezing, spray drying, etc. The aim of this review is to give an overview of the research on micelles (in vitro, in vivo and clinical) as delivery system for cancer treatment. Passive targeting is one route for accumulation of nanosized micellar drug formulations. Many research groups from both academia and industry focus on developing new strategies for improving the therapeutic efficacy of micellar systems (active targeting to the tumor site, designing multidrug delivery systems for overcoming multidrug resistance or micelles formed by prodrug conjugates, etc). There is only one micellar drug formulation in South Korea that has reached clinical practice. However, there are many untargeted anticancer drug loaded micellar formulations in clinical trials, which have potential for use in clinics. Many more products are expected to be on the market in the near future.


Controlled release of vancomycin from biodegradable microcapsules
Ozalp, Y; Ozdemir, N; Kocagoz, S; Hasırcı, Vasıf Nejat (2001-01-01)
Poly D,L-lactic acid (PLA) and its copolymers with glycolide PLGA 90:10 and 70:30 were polymerized under various conditions to yield polymers in the molecular weight range 12 000-40 000 daltons, as determined by gel permeation chromatography. Vancomycin hydrochloride was the hydrophilic drug of choice for the treatment of methicillin resistant Staphyloccoccal infections. It was microencapsulated in the synthesized polymers using water-oil-water (w/o/w) double emulsion and solvent evaporation. The influence ...
DFT investigation of high temperature water gas shift reaction on chromium-iron mixed oxide catalyst
Yalcin, Ozgen; Önal, Işık (2014-11-20)
As part of high temperature water gas shift reaction mechanism, CO adsorption and H2O adsorption on Fe3O4 (111) and chromium atom substituted Fe3O4 (111) slab surfaces are investigated by means of periodic DFT approach using VASP. Fe3O4 bulk structure has been computed including the Hubbard (U) parameter. One oxygen site (Ooct1) is studied as a probable site among the six Fe3O4 (111) terminations. Cr atom substitution on this surface is also examined. Cr atoms prefer being on the surface rather than in the ...
Crosslinked polyDADMAC gels as highly selective and reusable arsenate binding materials
Pirgalioglu, Saltuk; Ozbelge, Tulay A.; Özbelge, Hilmi Önder; Bicak, Niyazi (2015-02-15)
High porosity cationic hydrogels synthesized via crosslinking co-polymerization of diallyldimethylammonium chloride (DADMAC) with N,N'-tetraallylpiperaziniumdichloride (TAP) showed high affinity towards arsenate anions over a wide pH range within notably short periods. Batch tests indicated that poly(DADMAC) hydrogels removed 99% of the arsenate anions from aqueous solutions at pH 6-10 and exhibited a maximum arsenic removal capacity of 0.12 g arsenic per gram of hydrogel. DADMAC hydrogels performed well at...
Novel conversion of thiols into disulfides, via S-nitrosothiol intermediates using trichloronitromethane
Demir, Ayhan Sıtkı; Igdir, AC; Mahasneh, AS (1999-10-15)
An efficient oxidative coupling of thiols to give disulfides via thionitrite (S-nitrosothiol) intermediate is described using trichloronitromethane as an efficient reagent in organic solvents and water. Cysteine and glutathione are converted into the corresponding disulfides in water in high yields.
Genetic algorithm for estimating multiphase flow functions from unsteady-state displacement experiments
Akın, Serhat (1998-04-30)
Relative permeability and capillary pressure are the primary flow parameters required to model multiphase flow in porous media. Frequently, these properties are estimated on the basis of unsteady state laboratory displacement experiments. Interpretation of the flood process to obtain relative permeability data is performed by one of two means: application of frontal advance theory or direct computer simulation. Application of frontal advance theory requires a number of experimental restrictions such that th...
Citation Formats
D. Keskin and A. Tezcaner, “Micelles As Delivery System for Cancer Treatment,” CURRENT PHARMACEUTICAL DESIGN, pp. 5230–5241, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/47035.