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Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities
Date
2017-02-15
Author
Doğan, Özdemir
POLAT ÇAKIR, SIDIKA
Beksultanova, Nurzhan
ALTANLAR, NURTEN
Simsek, Duygu
KARABIYIK, HASAN
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity.
Subject Keywords
Oxide aziridinyl phosphonate
,
Phosphine oxide
,
Terminal aziridines
,
Aldehydes
,
Derivatives
,
Lithiation
,
Arylaziridines
,
2-Phosphonates
,
Miraziridine
,
Efficient
URI
https://hdl.handle.net/11511/47313
Journal
TETRAHEDRON-ASYMMETRY
DOI
https://doi.org/10.1016/j.tetasy.2017.01.003
Collections
Department of Chemistry, Article