Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities

Doğan, Özdemir
Beksultanova, Nurzhan
Simsek, Duygu
A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity.


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Citation Formats
Ö. Doğan, N. Beksultanova, N. ALTANLAR, D. Simsek, and H. KARABIYIK, “Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities,” TETRAHEDRON-ASYMMETRY, pp. 324–329, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/47313.