Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities

2017-02-15
Doğan, Özdemir
POLAT ÇAKIR, SIDIKA
Beksultanova, Nurzhan
ALTANLAR, NURTEN
Simsek, Duygu
KARABIYIK, HASAN
A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity.

Citation Formats
Ö. Doğan, S. POLAT ÇAKIR, N. Beksultanova, N. ALTANLAR, D. Simsek, and H. KARABIYIK, “Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities,” TETRAHEDRON-ASYMMETRY, vol. 28, no. 2, pp. 324–329, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/47313.