Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities

Date

2017-02-15

Author

Doğan, Özdemir
Beksultanova, Nurzhan
ALTANLAR, NURTEN
Simsek, Duygu
KARABIYIK, HASAN

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A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity.

Subject Keywords

Oxide aziridinyl phosphonate, Phosphine oxide, Terminal aziridines, Aldehydes, Derivatives, Lithiation, Arylaziridines, 2-Phosphonates, Miraziridine, Efficient

URI

https://hdl.handle.net/11511/47313

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2017.01.003

Collections

Department of Chemistry, Article

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Citation Formats

Ö. Doğan, N. Beksultanova, N. ALTANLAR, D. Simsek, and H. KARABIYIK, “Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities,” TETRAHEDRON-ASYMMETRY, pp. 324–329, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/47313.