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Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities

2017-02-15
Doğan, Özdemir
POLAT ÇAKIR, SIDIKA
Beksultanova, Nurzhan
ALTANLAR, NURTEN
Simsek, Duygu
KARABIYIK, HASAN
A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity.