Cell detection using a CMOS image sensor with modified pixel structure suitable for bio-chemical surface activation

Date

2013-04-02

Author

Musayev, Javid
Adiguzel, Yekbun
Külah, Haluk
Akın, Tayfun

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

109
views

0
downloads

This paper presents a CMOS image sensor with a 32 x 32 pixel array suitable for cell capture, detection, and quantification. Pixels measuring 15 mu m x 15 mu m have a modified structure, suitable for post-CMOS electroless gold plating, which enables surface activation for cell capture without the need for any intermediate layer. This structure also increases the detection probability of captured cells as opposed to non-captured ones, owing to a special light mask (metal shield) implemented on pixels. The light mask enables detection of cells as small as 3 mu m in diameter despite the larger pixel size. The proof of concept is demonstrated in this work by imaging yeast cells adsorbed on the sensor surface.

Subject Keywords

Noise, Gold, Photonics, Lighting, Lighting, Imaging, Arrays

URI

https://hdl.handle.net/11511/47827

DOI

https://doi.org/10.1109/memsys.2013.6474400

Collections

Department of Electrical and Electronics Engineering, Conference / Seminar

Suggestions

OpenMETU
Core

Capturing and detection of MCF-7 breast cancer cells with a CMOS image sensor Musayev, Javid; Altiner, Caglar; Adiguzel, Yekbun; Külah, Haluk; Eminoglu, Selim; Akın, Tayfun (2014-08-15) This paper presents a CMOS image sensor with a 32 x 32 pixel array for cell capture, detection, and quantification. Pixels measuring 15 pm x 15 mu m have a modified structure, suitable for post-CMOS electroless gold plating, which enables surface activation for cell capture without the need for any intermediate layer. This structure also increases the detection probability of captured cells, even when cells are much smaller than the pixel, owing to a special light mask implemented on pixels. Cells as small ...
MT6415CA: A 640x512-15 mu m CTIA ROIC for SWIR InGaAs Detector Arrays Eminoglu, Selim; Isikhan, Murat; Bayhan, Nusret; Gulden, M. Ali; Incedere, O. Samet; Soyer, S. Tuncer; Kocak, Serhat; Yilmaz, Gokhan S.; Akın, Tayfun (2013-05-03) This paper reports the development of a new low-noise CTIA ROIC (MT6415CA) suitable for SWIR InGaAs detector arrays for low-light imaging applications. MT6415CA is the second product in the MT6400 series ROICs from Mikro-Tasarim Ltd., which is a fabless IC design house specialized in the development of monolithic imaging sensors and ROICs for hybrid imaging sensors. MT6415CA is a low-noise snapshot CTIA ROIC, has a format of 640 x 512 and pixel pitch of 15 mu m, and has been developed with the system-on-chi...
DeepDistance: A multi-task deep regression model for cell detection in inverted microscopy images Koyuncu, Can Fahrettin; Gunesli, Gozde Nur; Atalay, Rengül; GÜNDÜZ DEMİR, Çiğdem (Elsevier BV, 2020-07-01) This paper presents a new deep regression model, which we call DeepDistance, for cell detection in images acquired with inverted microscopy. This model considers cell detection as a task of finding most probable locations that suggest cell centers in an image. It represents this main task with a regression task of learning an inner distance metric. However, different than the previously reported regression based methods, the DeepDistance model proposes to approach its learning as a multi-task regression pro...
A high performance Sigma-Delta readout circuitry for mu g resolution microaccelerometers Ocak, Ilker E.; Kepenek, Reha; Külah, Haluk; Akın, Tayfun (Springer Science and Business Media LLC, 2010-08-01) This paper reports a second order electromechanical sigma-delta readout for micro-g resolution accelerometers in addition to other high-sensitivity capacitive microsensors with large base capacitance. The chip implements a switched-capacitor readout front-end and an oversampled sigma-delta modulator, and hence can be used for both open-loop analog readout and closed-loop control and readout with direct digital output. The readout circuit has more than 115 dB dynamic range and can resolve less than 3 aF/root...
A High Throughput Lab-On-A-Chip System for Label Free Quantification of Breast Cancer Cells under Continuous Flow ASLAN, MUSTAFA YASİN; Yalçın, Yasemin; Ozgur, E.; Gündüz, Ufuk; Eminoglu, S.; Külah, Haluk; Akın, Tayfun (Elsevier BV; 2016-05-27) This paper presents an LOC system combining microfluidic DEP channel with a CMOS image sensor for label and lens free detection and real-time counting of MCF-7 cells under continuous flow. Trapped and then released MCF-7 cells are accurately detected and counted under flow with a CMOS image sensor integrated underneath the DEP channel, for the first time in the literature. CMOS image sensor can capture 391 frames per second (fps) that allows detection of the released cells flowing through the channel with a...

Citation Formats

J. Musayev, Y. Adiguzel, H. Külah, and T. Akın, “Cell detection using a CMOS image sensor with modified pixel structure suitable for bio-chemical surface activation,” 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/47827.