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Cell detection using a CMOS image sensor with modified pixel structure suitable for bio-chemical surface activation
Date
2013-04-02
Author
Musayev, Javid
Adiguzel, Yekbun
Külah, Haluk
Akın, Tayfun
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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This paper presents a CMOS image sensor with a 32 x 32 pixel array suitable for cell capture, detection, and quantification. Pixels measuring 15 mu m x 15 mu m have a modified structure, suitable for post-CMOS electroless gold plating, which enables surface activation for cell capture without the need for any intermediate layer. This structure also increases the detection probability of captured cells as opposed to non-captured ones, owing to a special light mask (metal shield) implemented on pixels. The light mask enables detection of cells as small as 3 mu m in diameter despite the larger pixel size. The proof of concept is demonstrated in this work by imaging yeast cells adsorbed on the sensor surface.
Subject Keywords
Noise
,
Gold
,
Photonics
,
Lighting
,
Lighting
,
Imaging
,
Arrays
URI
https://hdl.handle.net/11511/47827
DOI
https://doi.org/10.1109/memsys.2013.6474400
Collections
Department of Electrical and Electronics Engineering, Conference / Seminar
Citation Formats
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BibTeX
J. Musayev, Y. Adiguzel, H. Külah, and T. Akın, “Cell detection using a CMOS image sensor with modified pixel structure suitable for bio-chemical surface activation,” 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/47827.