Squaramide catalyzed alpha-chiral amine synthesis

Date

2018-10-17

Author

Karahan, SEDA
Tanyeli, Cihangir

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Enantiomerically pure alpha-chiral amines, have been commonly utilized as resolving agents and chiral auxiliaries and are currently found in 40% of active pharmaceutical ingredients. Hence, development of highly stereoselective metal-free protocols regarding atom-economy and large-scale applications becomes a major issue. In this respect, chiral bifunctional H-bonding squaramides have been successfully applied for both amine synthesis and functionalization of amines in the last decade. This survey summarizes asymmetric synthesis of chiral amines by various carbon-carbon and carbon-nitrogen bond formation with squaramide catalysis as a particular focus of interest. (C) 2018 Published by Elsevier Ltd.

Subject Keywords

Squaramide, Alpha-Chiral amine, Asymmetric organocatalysis, Bifunctional organocatalyst

URI

https://hdl.handle.net/11511/48083

Journal

TETRAHEDRON LETTERS

DOI

https://doi.org/10.1016/j.tetlet.2018.08.034

Collections

Department of Chemistry, Article

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Citation Formats

S. Karahan and C. Tanyeli, “Squaramide catalyzed alpha-chiral amine synthesis,” TETRAHEDRON LETTERS, pp. 3725–3737, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/48083.