Squaramide catalyzed alpha-chiral amine synthesis

Date

2018-10-17

Author

Karahan, SEDA
Tanyeli, Cihangir

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

6
views

0
downloads

Enantiomerically pure alpha-chiral amines, have been commonly utilized as resolving agents and chiral auxiliaries and are currently found in 40% of active pharmaceutical ingredients. Hence, development of highly stereoselective metal-free protocols regarding atom-economy and large-scale applications becomes a major issue. In this respect, chiral bifunctional H-bonding squaramides have been successfully applied for both amine synthesis and functionalization of amines in the last decade. This survey summarizes asymmetric synthesis of chiral amines by various carbon-carbon and carbon-nitrogen bond formation with squaramide catalysis as a particular focus of interest. (C) 2018 Published by Elsevier Ltd.

Subject Keywords

Squaramide, Alpha-Chiral amine, Asymmetric organocatalysis, Bifunctional organocatalyst

URI

https://hdl.handle.net/11511/48083

Collections

Department of Chemistry, Article