Antioxidant capacities of Gundelia tournefortii L. extracts and inhibition on glutathione-S-transferase activity

Date

2007-01-01

Author

Çoruh, Nursen
Ozgokce, F.
Iscan, M.

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

55
views

0
downloads

Gundelia tournefortii L. is an important food source and a well-known medicinal plant in Eastern Anatolia. Therapeutic effects of medicinal plants are known to be closely related to their antioxidant capacities. Antioxidant activities of G. tournefortii, both for the aerial parts and seeds, were investigated by using both 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and lipid peroxidation inhibition methods. The seeds were found to have higher antioxidant potential than the aerial, with IC50 values of 0.073 mg/mL for DPPH scavenging and 0.146 mg/mL for lipid peroxidation inhibition capacities. In addition, total phenolic contents of the Gundelia tournefortii L. extracts, especially the seed extracts correlates to its high antioxidant activity with 105.1 +/- 8.7 mu g gallic acid equivalents (GAEs) per mg of seed extract. Plant extracts with high phenolics content are known to have important effects on various enzymes, as well as glutathione-S-transferases, which are important detoxification enzymes in phase 11 systems with an important role in developing multi-drug resistance to chemotherapy in tumour cells. Consequently, the effects of G. tournefortii extracts on crude cytosolic glutathione-S-transferase was also studied and the seed extracts have shown effective inhibition of cytosolic GST activity, with an IC50 of 97.51 mu g/mL.

Subject Keywords

Food Science, Analytical Chemistry, General Medicine

URI

https://hdl.handle.net/11511/48906

Journal

FOOD CHEMISTRY

DOI

https://doi.org/10.1016/j.foodchem.2005.12.008

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

Use of Fourier transform infrared spectroscopy for rapid comparative analysis of Bacillus and Micrococcus isolates Garip, Sebnem; Gözen, Ayşe Gül; Severcan, FERİDE (Elsevier BV, 2009-04-15) The identification of foodborne microorganisms and their endospores in food products are important for food safety. The present work compares Bacillus (Bacillas licheniformis, Bacillus circulans and Bacillus silbtilis) and Micrococcus (Micrococcus luteus) species with Fourier transform infrared (FTIR) spectroscopy. Our results show that there are several characteristic peaks belonging to both the Micrococcus and Bacillus Species Which Call be used for the identification of these foodborne bacteria and their...
Differentiation of Anatolian honey samples from different botanical origins by ATR-FTIR spectroscopy using multivariate analysis Gok, Seher; Severcan, Mete; Goormaghtigh, Erik; KANDEMİR, İRFAN; Severcan, Feride (Elsevier BV, 2015-03-01) Botanical origin of the nectar predominantly affects the chemical composition of honey. Analytical techniques used for reliable honey authentication are mostly time consuming and expensive. Additionally, they cannot provide 100% efficiency in accurate authentication. Therefore, alternatives for the determination of floral origin of honey need to be developed. This study aims to discriminate characteristic Anatolian honey samples from different botanical origins based on the differences in their molecular co...
Anticarcinogenic Effects of the Ethanolic Extract of Salix aegyptiaca in Colon Cancer Cells: Involvement of Akt/PKB and MAPK Pathways Enayat, Shabnam; Ceyhan, Muserref Seyma; BAŞARAN, ARİF AHMET; Gürsel, Mayda; Banerjee, Sreeparna (Informa UK Limited, 2013-10-01) The bark from Salix species of plants has been traditionally consumed for its antiinflammatory properties. Because inflammation frequently accompanies the progress of colorectal cancer (CRC), we have evaluated the anticancer properties of the ethanolic extract from the bark (EEB) of S. aegyptiaca, a Salix species endogenous to the Middle East, using HCT-116 and HT29 CRC cell lines. Fresh bark from S. aegyptiaca was extracted with ethanol, fractionated by solvent-solvent partitioning and the fractions were a...
Survey of 55 Turkish Salvia taxa for their acetylcholinesterase inhibitory and antioxidant activities ŞENOL, FATMA SEZER; ERDOĞAN ORHAN, İLKAY; Celep, Ferhat; Kahraman, Ahmet; Doğan, Musa; Yilmaz, Guelderen; ŞENER, BİLGE (Elsevier BV, 2010-05-01) In the current work, our target was to screen inhibitory potentials of 55 Turkish Salvia taxa, 28 of which are endemic, against acetylcholinesterase (AChE), which is a chief enzyme in pathogenesis of Alzheimer's disease (AD). The dichloromethane, ethyl acetate, and methanol extracts prepared from 55 Salvia taxa were tested for their AChE inhibitory activity at 25, 50, and 100 mu g/ml using an ELISA microplate reader. The extracts were also screened for their scavenging effect against DPPH radical and iron-c...
Cloning of the scytalidium thermophilum bifunctional catalase / phenol oxidase gene and expression in aspergillus sojae Erçin, Hatice Özlem; Ögel, Zümrüt Begüm; Department of Food Engineering (2008) Scytalidium thermophilum is a thermophilic fungus with an important role in the composting process of mushroom cultivation. An extracellular phenol oxidase of Scytalidium thermophilum (STEP) with novel features was previously studied in our laboratory. This enzyme later turned out to be a catalase having phenol oxidase activity. The aim of this study was to clone Scytalidium thermophilum bifunctional catalase/phenol oxidase encoding gene and express the gene in Aspergillus sojae for future site directed mut...

Citation Formats

N. Çoruh, F. Ozgokce, and M. Iscan, “Antioxidant capacities of Gundelia tournefortii L. extracts and inhibition on glutathione-S-transferase activity,” FOOD CHEMISTRY, pp. 1249–1253, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/48906.