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IR and turbidity studies of vitamin E-cholesterol-phospholipid membrane interactions

Severcan, Feride
Kazanci, Nadide
Baykal, Ülkü
Süzer, Şefik
Binary and tertiary mixture of α-tocophenol, cholesterol and dimyristoylphosphatidylcholine in the form of multilamellar liposomes were investigated by Fourier Transform Infrared and visible spectroscopy. Results of the FTIR and turbidity experiments indicate that α T decreases or diminishes the effect of cholesterol on the frequency and the bandwidth of the C-H stretching, CH2 scissoring and C=O stretching bands in FTIR spectra and the turbidity measurements (recorded as absorbance values at 440 nm) in phospholipid model membranes.