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Melatonin affects the order, dynamics and hydration of brain membrane lipids
Date
2007-05-27
Author
Akkaş, Sara Banu
Zorlu, Faruk
Severcan, Feride
Metadata
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The brain is especially susceptible to free radical attack since it is rich in polyunsaturated fatty acids and consumes very high amounts of oxygen. Melatonin is a non-enzymatic amphiphilic antioxidant hormone that is widely used in medicine for protective and treatment purposes in cases of oxidative stress. In the present work, the effects of the clinically used dose of melatonin (a single intraperitoneal dose of 100 mg/kg) on rat brain homogenate were investigated as a function of temperature using Fourier transform infrared spectroscopy. The results showed that the lipid to protein ratio decreases in the melatonin treated brain samples. Moreover, it is revealed that melatonin disorders and decreases the dynamics of lipids and induces a strengthening in the hydrogen bonding between the functional groups of both melatonin and the polar parts of lipids and/or water at physiological temperatures.
Subject Keywords
Inorganic Chemistry
,
Organic Chemistry
,
Analytical Chemistry
,
Spectroscopy
URI
https://hdl.handle.net/11511/51592
Journal
JOURNAL OF MOLECULAR STRUCTURE
DOI
https://doi.org/10.1016/j.molstruc.2006.12.018
Collections
Department of Biology, Article
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S. B. Akkaş, F. Zorlu, and F. Severcan, “Melatonin affects the order, dynamics and hydration of brain membrane lipids,”
JOURNAL OF MOLECULAR STRUCTURE
, pp. 207–215, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51592.