Melatonin affects the order, dynamics and hydration of brain membrane lipids

Akkaş, Sara Banu
Zorlu, Faruk
Severcan, Feride
The brain is especially susceptible to free radical attack since it is rich in polyunsaturated fatty acids and consumes very high amounts of oxygen. Melatonin is a non-enzymatic amphiphilic antioxidant hormone that is widely used in medicine for protective and treatment purposes in cases of oxidative stress. In the present work, the effects of the clinically used dose of melatonin (a single intraperitoneal dose of 100 mg/kg) on rat brain homogenate were investigated as a function of temperature using Fourier transform infrared spectroscopy. The results showed that the lipid to protein ratio decreases in the melatonin treated brain samples. Moreover, it is revealed that melatonin disorders and decreases the dynamics of lipids and induces a strengthening in the hydrogen bonding between the functional groups of both melatonin and the polar parts of lipids and/or water at physiological temperatures.


Molecular investigation of the effects of antioxidants on rat brain tissues
Akkaş, Sara Banu; Severcan, Feride; Department of Biological Sciences (2003)
The brain is highly susceptible to free radical damage since it is rich in polyunsaturated fatty acids and consumes very high amounts of oxygen. In this study, the effects on rat brain tissue of several antioxidants, namely lipoic acid, vitamin E and melatonin, were examined as the control studies of further research, in which their ability to protect the rat brain tissue from oxidative stress will be investigated. The tool of investigation selected was Fourier Transform Infrared Spectroscopy (FTIR) because...
Novel Pt(II) complexes containing pyrrole oxime, synthesis, characterization and DNA binding studies
Altunöz Erdoğan, Deniz; Ozalp-Yaman, Seniz (Elsevier BV, 2014-05-05)
Since the discovery of anticancer activity and subsequent clinical success of cisplatin (cis-[PtCl2(NH3)(2)]), platinum-based compounds have since been widely synthesized and studied as potential chemotherapeutic agents. In this sense, three novel nuclease active Pt(II) complexes with general formula; [Pt(NH3)CI(L)] (1), [Pt(L)(2)] (2), and K[PtCl2(L)] (3) in which L is 1-H-pyrrole-2-carbaldehyde oxime were synthesized. Characterization of complexes was performed by elemental analysis, FT-IR, H-1 NMR and ma...
Acyl chain length and charge effect on Tamoxifen-lipid model membrane interactions
Bilge, Duygu; KAZANCI, NADİDE; Severcan, Feride (Elsevier BV, 2013-05-22)
Tamoxifen (TAM), which is an antiestrogenic agent, is widely used during chemotherapy of breast, pancreas, brain and liver cancers. In this study, TAM and model membrane interactions in the form of multilamellar vesicles (MLVs) were studied for lipids containing different acyl chain length and different charge status as a function of different TAM (1, 6, 9 and 15 mol%) concentrations. Zwitterionic lipids namely dipalmitoyl phosphatidylcholine (DPPC), and dimyristoylphosphatidylcholine (DMPC) lipids were use...
Evaluation and discrimination of simvastatin-induced structural alterations in proteins of different rat tissues by FTIR spectroscopy and neural network analysis
Garip, Sebnem; Yapici, Engin; Ozek, Nihal Simsek; Severcan, Mete; Severcan, Feride (Royal Society of Chemistry (RSC), 2010-01-01)
Statins are commonly used to control hypercholesterolemia and to prevent cardiovascular diseases. Among the statins, Simvastatin is one of the most frequently prescribed statins because of its efficacy in reducing LDL lipoprotein cholesterol levels, its tolerability, and its reduction of cardiovascular risk and mortality. Conflicting results have been reported with regard to benefits (pleiotropic effects) as well as risks (adverse effects) of simvastatin on different soft and hard tissues. In the current st...
Atorvastatin-loaded SBA-16 nanostructures: Synthesis, physical characterization, and biochemical alterations in hyperlipidemic rats
Sayadi, Khalilolah; Rahdar, Abbas; Hajinezhad, Mohammad Reza; Nikazar, Sohrab; Susan, Md Abu Bin Hasan (Elsevier BV, 2020-02-15)
Mesoporous Santa Barbara Amorphous-16 (SBA-16) silica was synthesized via facile sol-gel method and functionalized using a silanizing agent, 3-amino-propyl-triethoxysilane, cyanuric chloride and dopamine. SBA-16/dopamine was characterized for the structure and morphology by x-ray diffraction, transmission electron microscopy, thermogravimetric analysis, and Fourier-transform infrared spectroscopy. Silica was amorphous in nature. Analysis of SBA-16 silica by Brunauer-Emmett-Teller (BET) method indicated that...
Citation Formats
S. B. Akkaş, F. Zorlu, and F. Severcan, “Melatonin affects the order, dynamics and hydration of brain membrane lipids,” JOURNAL OF MOLECULAR STRUCTURE, pp. 207–215, 2007, Accessed: 00, 2020. [Online]. Available: