Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Investigation of diabetes-induced effect on apex of rat heart myocardium by using cluster analysis and neural network approach: An FTIR study
Download
10.1155:2007:269618.pdf
Date
2007
Author
Toyran, Neslihan
Severcan, Feride
Severcan, Mete
Turan, Belma
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
45
views
42
downloads
Cite This
Diabetes mellitus (DM) is a progressive chronic disorder, which affects people belonging to all age groups of the population. This disease is accompanied by a greatly increased risk of cardiovascular death. In the present study, the effects of streptozotocin (STZ)-induced type 1 diabetes on apex myocardium of the rat heart have been investigated using Fourier Transform Infrared (FTIR) spectra. The cluster analysis has been applied to FTIR spectra to differentiate the diabetic samples from the normal controls. In addition, the protein secondary structures of diabetic and normal tissues were predicted by neural networks based on the amide I band of the FTIR spectra. The findings mainly suggest that 5 weeks of diabetes alters the lipid and protein profile of normal rat heart apex myocardium, which might have an important role in understanding the molecular mechanism of diabetes-related heart diseases.
Subject Keywords
Diabetes
,
FTIR
,
Cluster analysis
,
Neural networks
,
Protein secondary structure prediction
,
Apex myocardium
URI
https://hdl.handle.net/11511/51737
Journal
Spectroscopy
DOI
https://doi.org/10.1155/2007/269618
Collections
Department of Biology, Article
Suggestions
OpenMETU
Core
Diabetes induces compositional, structural and functional alterations on rat skeletal soleus muscle revealed by FTIR spectroscopy: a comparative study with EDL muscle
Bozkurt, Ozlem; Severcan, Mete; Severcan, Feride (2010-01-01)
Diabetes Mellitus (DM) is a metabolic disorder, characterized by abnormally high blood glucose levels due to decreased secretion or effectiveness in function of insulin. Having a role in carbohydrate and lipid metabolism, skeletal muscle is affected by the absence of insulin in diabetic conditions. This current study reports the application of Fourier transform infrared (FTIR) spectroscopy in the determination of macromolecular alterations in streptozotocin (STZ)-induced diabetic rat skeletal Soleus (SOL) m...
A direct role of collagen glycation in bone fracture
Poundarik, Atharva A.; Wu, Ping-Cheng; Evis, Zafer; Sroga, Grazyna E.; Ural, Ani; Rubin, Mishaela; Vashishth, Deepak (2015-12-01)
Non-enzymatic glycation (NEG) is an age-related process accelerated by diseases like diabetes, and causes the accumulation of advanced glycation end-products (AGEs). NEG-mediated modification of bone's organic matrix, principally collagen type-I, has been implicated in impairing skeletal physiology and mechanics. Here, we present evidence, from in vitro and in vivo models, and establish a causal relationship between collagen glycation and alterations in bone fracture at multiple length scales. Through atomi...
Characterization of STING mediated innate immune sensing in the context of pathology
Şanlı, Hatice Asena; Gürsel, Mayda; Department of Molecular Biology and Genetics (2018)
Type I interferonopathies are a group of diseases characterized by excess type I interferon production. Here, we examined the intracellular signal transduction pathways of two interferonopathies, STING-associated vasculopathy with Onset in Infancy (SAVI) and Aicardi-Goutières syndrome (AGS) using in vitro cell line models. SAVI is characterized by constitutive STING activation. M155V and N154S gain-of-function mutations in STING can cause disease in humans. We expressed the M155V mutant STING in STING-knock...
Evaluation of Whole Genome Association Study Data in Bipolar Disorders: Potential Novel SNPs and Genes
CENGİZ HAN, Açıkel; Aydın Son, Yeşim; ÇELİK, Cemil; RECEP, Tütüncü (2015-03-01)
Objective: As a result of studies of multifactorial conditions, genetic, physiological and environmental factors, the overall heritability of bipolar disorders has been estimated to be up to 70%. In this study, an analysis of genome-wide association study data using data mining algorithms has revealed single-nucleotide polymorphisms that may be the basis for the molecular etiology of bipolar disorders.
Investigation of drug-related changes on bone tissues of rat animal models in healthy and disease states
Garip, Şebnem; Severcan, Feride; Banerjee, Sreeparna; Department of Biochemistry (2012)
Disease- and drug-related bone disorders are rapidly increasing in the population. The drugs which are used for the treatment of neurodegenerative diseases and metabolic derangements, may have negative or positive effects on bone tissues. In the first study, the possible side-effects of Carbamazepine and epileptic seizures on bone structure and composition were investigated by FTIR and synchrotron-FTIR microspectroscopy, AFM and micro- and nano-hardness analysis. The effects on the blood parameters, bone tu...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
N. Toyran, F. Severcan, M. Severcan, and B. Turan, “Investigation of diabetes-induced effect on apex of rat heart myocardium by using cluster analysis and neural network approach: An FTIR study,”
Spectroscopy
, pp. 269–278, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51737.