Chemoenzymatic synthesis of both enantiomers of 2-chloro-1-(2-furyl)ethanol

Date

2005-05-23

Author

Gercek, Z
Karakaya, D
Demir, Ayhan Sıtkı

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Enzyme catalyzed transesterification of rac-2-chloro-1-(2-furyl)ethanol rac-1 using vinyl acetate afforded the enantiomers of 2-chloro-1-(2-furyl)ethanol 1 and 2-chloro-1-(2-furyl)ethyl acetate 2 in high enantiomeric excess. Several lipases were used for the kinetic resolution of racemic 2-chloro-1-(2-furyl)ethanol l, in which the lipases from Pseudomonas cepacia, Candida antarctica and Candida cylindracea displayed high enantioselectivity towards 1.

Subject Keywords

Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Catalysis

URI

https://hdl.handle.net/11511/52007

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2005.04.007

Collections

Department of Chemistry, Article

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Citation Formats

Z. Gercek, D. Karakaya, and A. S. Demir, “Chemoenzymatic synthesis of both enantiomers of 2-chloro-1-(2-furyl)ethanol,” TETRAHEDRON-ASYMMETRY, pp. 1743–1746, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52007.