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Chemoenzymatic synthesis of both enantiomers of 2-chloro-1-(2-furyl)ethanol
Date
2005-05-23
Author
Gercek, Z
Karakaya, D
Demir, Ayhan Sıtkı
Metadata
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Enzyme catalyzed transesterification of rac-2-chloro-1-(2-furyl)ethanol rac-1 using vinyl acetate afforded the enantiomers of 2-chloro-1-(2-furyl)ethanol 1 and 2-chloro-1-(2-furyl)ethyl acetate 2 in high enantiomeric excess. Several lipases were used for the kinetic resolution of racemic 2-chloro-1-(2-furyl)ethanol l, in which the lipases from Pseudomonas cepacia, Candida antarctica and Candida cylindracea displayed high enantioselectivity towards 1.
Subject Keywords
Physical and Theoretical Chemistry
,
Inorganic Chemistry
,
Organic Chemistry
,
Catalysis
URI
https://hdl.handle.net/11511/52007
Journal
TETRAHEDRON-ASYMMETRY
DOI
https://doi.org/10.1016/j.tetasy.2005.04.007
Collections
Department of Chemistry, Article
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Z. Gercek, D. Karakaya, and A. S. Demir, “Chemoenzymatic synthesis of both enantiomers of 2-chloro-1-(2-furyl)ethanol,”
TETRAHEDRON-ASYMMETRY
, pp. 1743–1746, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52007.