Preparation and Characterization of Chitosan Containing Acrylic Bone Cement Formulations

Bone cements are used in orthopaedic surgery and dentistry, and the commonly used commercial ones are prepared from poly (methylmethacrylate) (PMMA). In orthopaedic surgery bone cements are used as filling agents for the treatment of damaged tissues and they are used to stabilize the prosthesis by providing the mechanical interlock between bone and metal during the use of metal prothesis and to provide the homogeneous distribution of applied load. In this study, bone cements compositions were prepared by using two different PMMA (microspheres prepared by suspension polymerization and ground and sieved PMMA particles). Compositions were prepared by addition of hydroxyapatite (HA) as inorganic load carrying substance, and barium sulphate (BaSO4) as opacifier. To increase biocompatibility of the prepared bone cements, natural polymer chitosan was added. It was observed that addition of chitosan had a positive effect on mechanical properties.
14th National Biomedical Engineering Meeting


Preparation and characterization of hydroxyapatite containing acrylic bone cements
Başgörenay, Burcu; Hasırcı, Nesrin; Department of Polymer Science and Technology (2004)
Acrylic bone cements are one of the most important biomaterials used in orthopaedic surgery and dental applications to fill the cavities or provide mechanical interlock between prosthesis and the bone. Their biocompatibility can be increased by addition of different materials into the formulation, such as hydroxyapatite. Besides all the advantages, bone cements have several drawbacks including tissue necrosis, chemical necrosis, shrinkage of the cement and aseptic loosening. Therefore painstaking research a...
Preparation and characterization of acrylic bone cements
Endoğan, Tuğba; Hasırcı, Nesrin; Department of Chemistry (2005)
Acrylic bone cements are used in dentistry and orthopedic surgery to fix prosthetic devices into the bone. Bone cements transfer and distribute the applied load and increase the load-carrying capacity of the prosthesis/cement/bone system with the help of mechanical bonding between the device and the bone. In spite of all their advantages, bone cements have several drawbacks such as insufficient mechanical properties, high exothermic polymerization temperature, release of monomer to the environmental tissue ...
Preparation and characterization of poly(epsilon-caprolactone) scaffolds modified with cell-loaded fibrin gel
Malikmammadov, Elbay; Endoğan Tanır, Tuğba; Kızıltay, Aysel; Hasırcı, Nesrin (2019-03-15)
Poly(epsilon-caprolactone) (PCL) is one of the most commonly used polymers in the production of tissue engineered scaffolds for hard tissue treatments. Incorporation of cells into these scaffolds significantly enhances the healing rate of the tissue. In this study, PCL scaffolds were prepared by wet spinning technique and modified by addition of fibrinogen in order to form a fibrin network between the PCL fibers. By this way, scaffolds would have micro and nanofibers in their structures. Drying of the wet s...
Investigation of surface structure and biocompatibility of chitosan-coated zirconia and alumina dental abutments
Kalyoncuoglu, Ulku Tugba; Yilmaz, Bengi; Koc, Serap Gungor; Evis, Zafer; ARPACI, PEMBEGÜL UYAR; Kansu, Gulay (Wiley, 2018-12-01)
Background: For long-term success of dental implants, it is essential to maintain the health of the surrounding soft tissue barrier, which protects the bone-implant interface from the microorganisms. Although implants based on titanium and its alloys still dominate the dental implant market, alumina (Al2O3) and zirconia (ZrO2) implant systems are widely used in the area. However, they provide smooth and bioinert surfaces in the transmucosal region, which poorly integrate with the surrounding tissues.
Preparation of anti-adhesive and antibacterial surfaces using polymers
Onat, Bora; İErel Göktepe, İrem; Banerjee, Sreeparna; Department of Biotechnology (2017)
Layer-by-layer self-assembly of polymers is a versatile technique which can impart new functions to the surfaces of biomedical instruments and biomaterials. Materials which are coated by this technique can exhibit response towards environmental stimuli, such that the controlled release of drugs and similar biologically functional molecules under different stimuli can be observed. In the span of this thesis study, ultra-thin polymer films were prepared through the layer-by-layer self-assembly technique, the ...
Citation Formats
T. Endogan, A. Kızıltay, and N. Hasırcı, “Preparation and Characterization of Chitosan Containing Acrylic Bone Cement Formulations,” presented at the 14th National Biomedical Engineering Meeting, Izmir, Turkey, 2009, Accessed: 00, 2020. [Online]. Available: