Preparation and characterization of hydroxyapatite containing acrylic bone cements

Download
2004
Başgörenay, Burcu
Acrylic bone cements are one of the most important biomaterials used in orthopaedic surgery and dental applications to fill the cavities or provide mechanical interlock between prosthesis and the bone. Their biocompatibility can be increased by addition of different materials into the formulation, such as hydroxyapatite. Besides all the advantages, bone cements have several drawbacks including tissue necrosis, chemical necrosis, shrinkage of the cement and aseptic loosening. Therefore painstaking research and study are carried out on development of new formulations to improve mechanical and thermal properties as well as biocompatibilities. In this study, bone cements with different compositions were prepared and new formulations were examined to improve mechanical properties and to reduce maximum curing temperature. It was observed that addition of hydroxyapatite, while keeping polymer-to-monomer ratio constant at 2.0, decreased curing temperature and increased compressive strength about 11% (Group-C) when hydroxyapatite addition was 12%. Further addition of hydroxyapatite destroyed homogeneity of the cement dough and made it difficult to handle. The composition which contains 8% hydroxyapatite was chosen as the optimum composition in respect of mechanical properties with 102.62°C curing temperature. In order to decrease the curing temperature ammonium nitrate this gives endothermic reactions with water, was added into the formulations. Addition of 0.5 g NH4NO3 decreased curing temperature from 94°C to 79.3°C while compressive strength kept in acceptable range with 95.99 MPa. Experiments demonstrated that the proposed formulation is acceptable for workability, homogeneity, mechanical strength and thermal properties. Further studies especially on curing temperature and biocompatibility should be achieved.

Suggestions

Preparation and characterization of acrylic bone cements
Endoğan, Tuğba; Hasırcı, Nesrin; Department of Chemistry (2005)
Acrylic bone cements are used in dentistry and orthopedic surgery to fix prosthetic devices into the bone. Bone cements transfer and distribute the applied load and increase the load-carrying capacity of the prosthesis/cement/bone system with the help of mechanical bonding between the device and the bone. In spite of all their advantages, bone cements have several drawbacks such as insufficient mechanical properties, high exothermic polymerization temperature, release of monomer to the environmental tissue ...
Composition-property relationship of PCL based Polyurethanes
Güney, Aysun; Hasırcı, Nesrin; Department of Polymer Science and Technology (2012)
The desirable properties of polyurethanes (PUs) such as mechanical flexibility associated with chemical versatility make these polymers attractive in the development of biomedical devices. In this study, various segmented polyurethanes were synthesized through polymerization reactions between polycaprolactone (PCL) diol or triol and excess hexamethylene diisocyanate (HDI) with varying NCO/OH ratios and the effect of composition on the properties of the resultant polyurethane films were examined. Initially, ...
Preparation and Characterization of Chitosan Containing Acrylic Bone Cement Formulations
Endogan, Tugba; Kızıltay, Aysel; Hasırcı, Nesrin (2009-05-22)
Bone cements are used in orthopaedic surgery and dentistry, and the commonly used commercial ones are prepared from poly (methylmethacrylate) (PMMA). In orthopaedic surgery bone cements are used as filling agents for the treatment of damaged tissues and they are used to stabilize the prosthesis by providing the mechanical interlock between bone and metal during the use of metal prothesis and to provide the homogeneous distribution of applied load. In this study, bone cements compositions were prepared by us...
Synthesis and surface modification studies of biomedical polyurethanes to improve long term biocompatibility
Aksoy, Eda Ayşe; Hasırcı, Nesrin; Department of Polymer Science and Technology (2008)
Thrombus formation and blood coagulation is a major problem associated with blood contacting products such as catheters, vascular grafts and artificial hearts. An intense research is being conducted towards the synthesis of new hemocompatible materials and mdifications of surfaces with biological molecules. In this study, polyurethane (PU) films were synthesized in medical purity from diisocyanate and polyol without using any other ingredients and the chemical, thermal and mechanical properties were charact...
Characterization of serpentine filled polypropylene
Can, Semra; Tinçer, Teoman; Department of Polymer Science and Technology (2008)
In this study, the aim is to prepare polypropylene (PP)/serpentine composites and study their mechanical, thermal and morphological properties. Another objective is to explore whether it is possible to have PP/serpentine nanocomposites with melt intercalation method by using the advantage of the layer silicate structure of serpentine. The most widely used fillers in PP are talc and mica which belong to the phyllosilicates group of silicate minerals. So far, there has been almost no study employing serpentin...
Citation Formats
B. Başgörenay, “Preparation and characterization of hydroxyapatite containing acrylic bone cements,” M.S. - Master of Science, Middle East Technical University, 2004.