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Synthesis of ferrocenyl substituted pyrazoles as potential antitumor substances
Date
2005-08-28
Author
Zora, Metin
Gormen, M
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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https://hdl.handle.net/11511/54086
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Department of Chemistry, Conference / Seminar
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Spiro cyclic molecules have gained significance because of their biological activities and electronic properties. Spiro frameworks are present in importance natural products and optoelectronic materials. Moreover, due to steric strain, the presence of a spiro carbon atom induces easy rearrangements that can lead to different cyclic products. Although there are some methods to synthesize spiro compounds, the synthesis of iodo-substituted spiro-fused pyridines have not been studied. Accordingly, in this thesis...
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Over the last decades, peptides have been heavily studied and proven beneficial in drug industry due to their high selectivity and potency compared to small organic molecules. A biologically and pharmaceutically significant peptide, chlorotoxin (CLTX), is one of the important peptide used in cancer studies. It is a neurotoxin, isolated from the venom matrix of Israeli Scorpion, Leirius quinquestriatus and it contains 36 amino acids and four disulfide bridges at a molecular mass of about 4 kDa. CLTX is mostl...
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A convenient one-pot synthesis of ferrocenyl-substituted quinolines via a molecular iodine-catalyzed reaction of ferrocenylimines with enolizable aldehydes is reported. First, nucleophilic addition of the in situ generated enol to ferrocenylimine produces beta-anilinopropionaldehyde, which then undergoes intramolecular Friedel-Crafts reaction to give dihydroquinoline derivative. Finally, subsequent dehydration and aerobic oxidation affords ferrocenyl quinolines.
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M. Zora and M. Gormen, “Synthesis of ferrocenyl substituted pyrazoles as potential antitumor substances,” 2005, vol. 230, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/54086.