Synthesis of ferrocenyl substituted pyrazoles as potential antitumor substances

Zora, Metin
Gormen, M


Synthesis of Iodo-substituted spiro-fused pyridine derivatives
Teke, Ecem; Zora, Metin; Department of Chemistry (2014)
Spiro cyclic molecules have gained significance because of their biological activities and electronic properties. Spiro frameworks are present in importance natural products and optoelectronic materials. Moreover, due to steric strain, the presence of a spiro carbon atom induces easy rearrangements that can lead to different cyclic products. Although there are some methods to synthesize spiro compounds, the synthesis of iodo-substituted spiro-fused pyridines have not been studied. Accordingly, in this thesis...
Synthesis of ferrocenyl quinones and polyquinanes
Eralp, Tuğçe; Zora, Metin; Department of Chemistry (2005)
With the discovery of antitumor activity of ferrocene derivatives, research on new ferrocene derivatives have gained importance. For this purpose, we have investigated the synthesis of ferrocenyl quinones starting from squaric acid. Several quinone derivatives are known to have antitumor and antibiotic activities. In this research, by combining ferrocene and quinone moieties, we have targeted ferrocenyl quinones which are supposed to have enhanced potential antitumor activity. Thermolysis of ferrocenyl-subs...
Synthesis of chlorotoxin and its derivatives as enzyme inhibitors
Kesici, Mehmet Seçkin; Özçubukçu, Salih; Özen, Can; Department of Chemistry (2017)
Over the last decades, peptides have been heavily studied and proven beneficial in drug industry due to their high selectivity and potency compared to small organic molecules. A biologically and pharmaceutically significant peptide, chlorotoxin (CLTX), is one of the important peptide used in cancer studies. It is a neurotoxin, isolated from the venom matrix of Israeli Scorpion, Leirius quinquestriatus and it contains 36 amino acids and four disulfide bridges at a molecular mass of about 4 kDa. CLTX is mostl...
Synthesis of ferrocenyl quinones
Zora, Metin; Acikalin, S (Elsevier BV, 2003-03-03)
A squarate-based synthesis of ferrocenyl quinones is described. Thermolysis of ferrocenyl-substituted cyclobutenones, prepared from ferrocenyl cyclobutenediones and alkenyllithiums, affords hydroquinones, which furnish, upon oxidation, ferrocenyl quinones. Ferrocenyl cyclobutenediones have been prepared from known cyclo butenediones by nucleophilic addition of ferrocenyllithium followed by hydrolysis, Pd/Cu-cocatalyzed cross-coupling with (tri-n-butylstannyl)ferrocene or Friedel-Crafts alkylation with ferro...
Synthesis of ferrocenyl quinolines
Zora, Metin (Elsevier BV, 2008-06-01)
A convenient one-pot synthesis of ferrocenyl-substituted quinolines via a molecular iodine-catalyzed reaction of ferrocenylimines with enolizable aldehydes is reported. First, nucleophilic addition of the in situ generated enol to ferrocenylimine produces beta-anilinopropionaldehyde, which then undergoes intramolecular Friedel-Crafts reaction to give dihydroquinoline derivative. Finally, subsequent dehydration and aerobic oxidation affords ferrocenyl quinolines.
Citation Formats
M. Zora and M. Gormen, “Synthesis of ferrocenyl substituted pyrazoles as potential antitumor substances,” 2005, vol. 230, Accessed: 00, 2020. [Online]. Available: