Cellular internalization of polyhydroxybutyrate coated magnetic nanoparticles in SKBR-3 cell lines

Cellular internalization of Bortezomib loaded CS MNPs by cervical cancer cells Unsoy, G.; Yalcin, S.; Khodadust, R.; Mutlu, Pelin; Pourianazar, N. Taghavi; Gündüz, Ufuk (2014-09-01)
Folic acid-conjugated polyethylene glycol-coated magnetic nanoparticles for doxorubicin delivery in cancer chemotherapy: Preparation, characterization and cytotoxicity on HeLa cell line Erdem, Murat; Gündüz, Ufuk (2017-08-01) Conventional chemotherapy is the most valid method to cope with cancer; however, it has serious drawbacks such as decrease in production of blood cells or inflammation of the lining of the digestive tract. These side effects occur since generally the drugs used in chemotherapy are distributed evenly within the body of the patient and cannot distinguish the cancer cells from the healthy ones. In this study, folic acid (FA)-conjugated, polyethylene-coated magnetic nanoparticles (FA-MNPs), and doxorubicin (Dox...
Nanoparticle-based drug delivery in cancer: the role of cell membrane structures Yalcin, Serap; Ozluer, Ozlem; Gündüz, Ufuk (2016-11-01) Development of novel drug-delivery systems aims to specifically deliver anticancer drugs to tumor tissues and improve the efficiency of chemotherapy, while minimizing side effects of drugs on healthy tissues and organs. However, drug-delivery systems are confronted by membrane barriers and multiple drug resistance in cancer cells. In recent years, the obtained results indicate an important role of lipids, proteins and carbohydrates in apoptosis, drug transport and the process of cellular uptake of nanoparti...
Polyhydroxybutyrate-Coated Magnetic Nanoparticles for Doxorubicin Delivery: Cytotoxic Effect Against Doxorubicin-Resistant Breast Cancer Cell Line Yalcin, Serap; Unsoy, Gozde; Mutlu, Pelin; Khodadust, Rouhollah; Gündüz, Ufuk (2014-11-01) In this study, polyhydroxybutyrate (PHB)-coated magnetic nanoparticles (MNPs) were prepared by coprecipitation of iron salts (Fe2+ and Fe3+) by ammonium hydroxide. Characterizations of PHB-coated MNPs were performed by Fourier transform infrared spectroscopy, x-ray diffraction, dynamic light scattering, thermal gravimetric analysis, vibrating sample magnetometry, and transmission electron microscopy analyses. Doxorubicin was loaded onto PHB-MNPs, and the release efficiencies at different pHs were studied un...
Temperature estimation using magnetic nanoparticles: a simulation study. Onuker, Gamz; Gençer, Nevzat G..; Department of Electrical and Electronics Engineering (2019) Lately, in biomedical imaging systems, algorithms for providing the temperature data became more important both for diagnosis and for treatment. Aiming to serve this purpose, in this thesis study, it is planned to estimate the temperature data using magnetic nanoparticles; which are actually imaging tracers used in a new medical imaging modality, Magnetic Particle Imaging (MPI). Since the introduction of MPI, the effect of temperature changes on magnetic nanoparticles (MNPs) and their magnetic behavior, is ...

Citation Formats

S. Yalcin, P. Mutlu, G. Unsoy, M. Parsian, N. T. Pourianazar, and U. Gündüz, “Cellular internalization of polyhydroxybutyrate coated magnetic nanoparticles in SKBR-3 cell lines,” 2014, vol. 281, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/54602.