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Metabolic engineering design of an extracellular hGH synthesis system
Date
2005-08-01
Author
Senturk, B
Çalık, Pınar
Calik, G
Ozdamar, TH
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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https://hdl.handle.net/11511/54940
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Department of Chemical Engineering, Conference / Seminar
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The objectives of this thesis are investigation of, i) the effects of oxygen transfer conditions on recombinant protein production in Pichia pastoris strains designed with novel naturally occuring pyruvate kinase (PYK) promoter (PPYK) which is a potential promoter for recombinant protein production under low to moderate oxygen transfer conditions, and ii) influences of engineering with single- and multi- copy genes, in fed-batch fermentation processes. Production of recombinant human growth hormone (rhGH) b...
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The metabolic fluxes through the central carbon pathways in the bioprocesses for human leukocyte interferon (IFN-alpha(1)) and erythropoietin (EPO) overproductions by recombinant Bacillus sp, carrying the related human genes were determined separately, on two alternative carbon sources, i.e. glucose and citrate, which have different reduction degrees. In addition, the influence of the P/O ratio on the cell growth, IFN-alpha(1) and EPO productions were investigated. Thus, the potential influence of increased...
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B. Senturk, P. Çalık, G. Calik, and T. Ozdamar, “Metabolic engineering design of an extracellular hGH synthesis system,” 2005, vol. 118, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/54940.
