Chitosan-coated magnetic nanoparticles as vehicles for the delivery of the antitumor drug gemcitabine

Parsian, M.
Unsoy, G.
Mutlu, Pelin
Yalcin, S.
PourianAzar, N. Taghavi
Gündüz, Ufuk


Chitosan magnetic nanoparticles for pH responsive Bortezomib release in cancer therapy
ÜNSOY, GÖZDE; Yalcin, Serap; Khodadust, Rouhollah; Mutlu, Pelin; Onguru, Onder; Gündüz, Ufuk (2014-06-01)
The use of nanotechnology in cancer treatment offers exciting opportunities, including the possibility of destroying tumors with minimal damage to healthy tissue by novel targeted drug delivery systems. pH differences between healthy and tumor microenvironment provide pH responsive release of drugs at tumor site via smart nanoparticles. In this study, chitosan coated superparamagnetic iron oxide nanoparticles (CS MNPs) were in situ synthesized by ionic crosslinking method as nanocarrier systems and loaded w...
Chitosan microspheres and films used in controlled release
Uylukçuoğlu, Beyza; Hasırcı, Nesrin; Yılmaz, Elvan; Department of Chemistry (2003)
Thalassemia, a genetic blood disorder, occurs as a result of deformations of hemoglobin structures. Patients with thalassemia develop iron overload from chronic blood transfusions and require regular iron chelation to prevent potentially fatal iron-related complications. Deferiprone is a commercially available drug used as iron chelator for the treatment of thalassemia but the very long-term effectiveness is not clearly known yet. Therefore, some studies were carried out to find effective alternative drugs ...
Chitosan Polysaccharide Suppress Toll Like Receptor Dependent Immune Response
Tincer, Gizem; Bayyurt Kocabaş, Banu; Arica, Yakup M.; Gursel, Ihsan (2015-04-01)
Chitosan is a widely used vaccine or anti-cancer delivery vehicle. In this study, we investigated the immunomodulatory effect of chitosan/pIC nanocomplexes on mouse immune cells. Materials and methods: Proliferative and cytotoxic features of chitosan were tested via CCK-8 assay on RAW 264.7. IL-1b p roduction was a ssessed v ia E LISA f rom PEC s upernatants. T NF-a, and NO induction from chitosan treated RAW cells detected by ELISA and Griess assay, respectively. mRNA message levels of TLRs and cytokines o...
Chitosan-based wet-spun scaffolds for bioactive agent delivery
Ucar, Seniz; Yilgor, Pinar; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2013-12-05)
Use of scaffolds both as supporting materials at defect site and delivery vehicles for bioactive agents is a commonly employed strategy to aid in tissue repair and regeneration. In this study, fibrous meshes of chitosan were prepared by wet spinning and coated with alginate. BSA as a model protein and gentamicin as a model antibiotic were incorporated into the scaffolds in multiple loading models and their release kinetics were studied. The effects of structural form of scaffold and properties of bioactive ...
Chitosan PLGA nanofibers prepared by electrospinning for tissue engineering applications
Endoğan Tanır, Tuğba; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (null; 2013-06-20)
Citation Formats
M. Parsian, G. Unsoy, P. Mutlu, S. Yalcin, N. T. PourianAzar, and U. Gündüz, “Chitosan-coated magnetic nanoparticles as vehicles for the delivery of the antitumor drug gemcitabine,” 2014, vol. 281, Accessed: 00, 2020. [Online]. Available: