Polat, Gunseli Guven
Akgun, Ozlem Marti
Simsek, Berksan
Saracli, Mehmet Ali
Heper, Senem
Hasırcı, Vasıf Nejat
The aim of this study was to evaluate the antimicrobial effects of a newly developed anti-caries pH-sensitive controlled release system against Streptococcus mutans. For this purpose 9, 30, and 45 mg of NaF were placed in multilayer polymeric structures consisting of three layers: poly-L-lactide (PLLA), 8% Eudragit E 100 + Eudragit RS 100, and Chitosan. The amount of fluoride ion (F) released was determined with an ionmeter. In order to assess the effect of this antimicrobial material releasing NaF in a controlled manner on S. mutans, the proliferation of this organism was recorded by preparing test discs with a standard surface area containing the active ingredient. In all the groups the F release began when the pH fell under 5.5, after 6 hr, and the number of S. mutans declined. In conclusion, the newly developed controlled release system can release intraorally the fluoride ion with its anti-caries properties when the pH falls below 5.5 and it may help significantly to improve caries prevention.


Recombinant human growth hormone production by pichia pastoris and determination of its interaction with peptide ligands
İnankur, Bahar; Çalık, Pınar; Department of Chemical Engineering (2010)
In this study, the aim was to achieve high concentration of recombinant human growth hormone (rhGH) production by recombinant Pichia pastoris by investigating the effects of various operation parameters and to determine the suitable peptide ligand sequence that shows affinity and specificity to hGH. In this context, firstly the effect of temperature and Tween-20/80 addition on production and cell growth were investigated. While at T=30 and 32°C, there was no difference, at 27 and 25°C cell growth slowed dow...
Recombinant therapeutic protease production by Bacillus sp.
Korkmaz, Nuriye; Çalık, Pınar; Department of Chemical Engineering (2007)
The first aim of this study is the development of extracellular recombinant therapeutic protease streptokinase producing Bacillus sp., and the second aim is to determine fermentation characteristics for streptokinase production. In this context, the signal (pre-) DNA sequence of B.licheniformis (DSM1969) extracellular serine alkaline protease enzyme gene (subC: Acc. No. X03341) was ligated to 5’ end of the streptokinase gene (skc: Acc. No. S46536) by SOE (Gene Splicing by Overlap Extension) method through P...
Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens
Kavruk, M.; ÇELİKBIÇAK, ÖMÜR; Ozalp, V. C.; Borsa, B. A.; Hernandez, F. J.; BAYRAMOĞLU, GÜLAY; SALİH, BEKİR; ARICA, MEHMET YAKUP (2015-01-01)
In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.
Increased Serum Interleukin-23 Levels In Patients With Behcet Disease-Associated Uveitis
Gurses, Ozlem; Koc, Elcin Kartal (2014-04-01)
Purpose: The aim of this study is to compare the serum interleukin (IL) levels between the patients with extraocular manifestations of Behçet disease and Behçet disease-associated uveitis. Methods: This is a prospective study involving 12 patients with extraocular manifestations of Behçet disease and 16 patients with Behçet disease-associated uveitis. The patients are involved in this study according to declaration of Helsinki. Inclusion criteria for all patients consist of a positive HLA B51 tissue typing...
Fluoxetine-related ecchymosis treated with venlafaxine: a case report
Karas, Hakan; Yilmaz, Taner (2017-01-01)
Selective serotonin reuptake inhibitors (SSRIs) are known to have a relatively favourable side effect profile. In recent years, there has been an emphasis on the risk of upper gastrointestinal bleeding in patients taking SSRI antidepressants. Although they may have some effects on coagulation profile, ecchymosis is a rare clinical manifestation of these effects. Here, we report a 25-year-old female patient who was diagnosed with major depressive disorder and manifested spontaneous ecchymoses on her legs rap...
Citation Formats
G. G. Polat, O. M. Akgun, B. Simsek, M. A. Saracli, S. Heper, and V. N. Hasırcı, “FLUORIDE-CONTAINING ANTI-CARIES pH-SENSITIVE RELEASE SYSTEM AND ITS EFFECT ON STREPTOCOCCUS MUTANS,” FLUORIDE, pp. 458–466, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56170.