Differential efficiency of transcutaneous electrical nerve stimulation in dominant versus nondominant hands in fibromyalgia: placebo-controlled functional near-infrared spectroscopy study

Baltaci, Aysegul
Gökçay, Didem
Using functional near-infrared spectroscopy (fNIRS), modulation of hemodynamic responses by transcutaneous electrical nerve stimulation (TENS) during delivery of nociceptive stimulation was investigated in fibromyalgia (FM) patients and healthy controls for both hands. Two experiments were conducted: (1) median nerve stimulation with TENS and (2) painful stimulation using electronic von Frey filaments with TENS/placebo TENS. Mean Delta HbO(2) brain activity was compared across groups and conditions using factorial ANOVA. Dominant (right) hand stimulation indicated significant interactions between group and condition in both hemispheres. Post hoc results revealed that FM patients showed an increased activation in "pain + TENS" condition compared to the "pain + placebo TENS" condition while the brain activity patterns for these conditions in controls were reversed. Left-hand stimulation resulted in similar TENS effects (reduced activation for "pain + TENS" than " pain + placebo TENS") in both groups. TENS effects in FM patients might be manipulated by the stimulation side. While the nondominant hand was responsive to TENS treatment, the dominant hand was not. These results indicate that stimulation side might be an effective factor in FM treatment by using TENS. Future studies are needed to clarify the underlying mechanism for these findings. (c) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE).


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Eken, Aykut; Gökçay, Didem; Kara, Murat; Department of Medical Informatics (2016)
In this study, we investigated the difference in hemodynamic responses between fibromyalgia (FM) and healthy controls via functional near infrared spectroscopy (fNIRS) during application of painful stimulus and transcutaneous electrical nerve stimulation (TENS). We collected several clinical data (pain threshold, Beck Depression Inventory (BDI) score, Fibromyalgia Impact Questionnaire (FIQ) score, pain ratings) before and during the experiment. After data collection, we analyzed it using general linear mode...
Neural stimulation interface with ultra-low power signal conditioning circuit for fully-implantable cochlear implants
Ulusan, Hasan; Chamanian, Salar; Zorlu, Ozge; Muhtaroglu, Ali; Külah, Haluk (2018-03-23)
This paper presents an ultra-low power interface circuit to stimulate auditory nerves through fully-implantable cochlear implants (FICIs). The interface circuit senses signals generated from a multi-frequency piezoelectric sensor array, and generates neural stimulation current according to input sound level. Firstly, piezoelectric sensor output is amplified, and compressed with an ultra-low power logarithmic amplifier (LA). This significantly reduces power by eliminating the compression in the next stages. ...
Quantification of the Effects of Transcutaneous Electrical Nerve Stimulation With Functional Magnetic Resonance Imaging: A Double-Blind Randomized Placebo-Controlled Study
KARA, MURAT; ÖZÇAKAR, LEVENT; Gökçay, Didem; ÖZÇELİK, EROL; Yorubulut, Mehmet; Guneri, Sinem; KAYMAK, BAYRAM; AKINCI, AYŞEN; ÇETİN, ALP (Elsevier BV, 2010-08-01)
Objective: To evaluate the effects of transcutaneous electric nerve stimulation (TENS) by using functional magnetic resonance imaging (fMRI) in patients with carpal tunnel syndrome (CTS).
Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease
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Previous research suggests that oscillatory coupling between cortex, basal ganglia and muscles plays an important role in motor behavior. Furthermore, there is evidence that oscillatory coupling is altered in patients with movement disorders such as Parkinson's disease (PD).
Multiwalled CNT-pHEMA composite conduit for peripheral nerve repair.
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A nerve conduit is designed to improve peripheral nerve regeneration by providing guidance to the nerve cells. Conductivity of such guides is reported to enhance this process. In the current study, a nerve guide was constructed from poly(2-hydroxyethyl methacrylate) (pHEMA), which was loaded with multiwalled carbon nanotubes (mwCNT) to introduce conductivity. PHEMA hydrogels were designed to have a porous structure to facilitate the transportation of the compounds needed for cell nutrition and growth and al...
Citation Formats
A. EKEN, M. KARA, B. BASKAK, A. Baltaci, and D. Gökçay, “Differential efficiency of transcutaneous electrical nerve stimulation in dominant versus nondominant hands in fibromyalgia: placebo-controlled functional near-infrared spectroscopy study,” NEUROPHOTONICS, pp. 0–0, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57048.