Investigating pain perception in somatosensory cortex for healthy and fibromyalgia patient populations by using fNIRS

Eken, Aykut
In this study, we investigated the difference in hemodynamic responses between fibromyalgia (FM) and healthy controls via functional near infrared spectroscopy (fNIRS) during application of painful stimulus and transcutaneous electrical nerve stimulation (TENS). We collected several clinical data (pain threshold, Beck Depression Inventory (BDI) score, Fibromyalgia Impact Questionnaire (FIQ) score, pain ratings) before and during the experiment. After data collection, we analyzed it using general linear model (GLM) and we applied classification methods to determine which cortical structures are important in discriminating healthy and patient groups. Our study showed that TENS effect was observed in both hands of healthy controls, but only left hand of FM patients. However, there is an opposite effect observed when the right hand of FM patients is stimulated. These findings indicate that the pain perception mechanism in FM syndrome needs further investigation since the outcome of the TENS treatment differs with respect to hands. When classification is done using SVM using features from the painful stimulation experiment, an accuracy of %90 is observed in distinguishing patients from healthy controls.  


Measurement of AC magnetic field distribution using magnetic resonance imaging
Ider, YZ; Muftuler, LT (1997-10-01)
Electric currents are applied to body in numerous applications in medicine such as electrical impedance tomography, cardiac defibrillation, electrocautery, and physiotherapy. If the magnetic field within a region is measured, the currents generating these fields can be calculated using the curl operator. In this study, magnetic fields generated within a phantom by currents passing through an external wire is measured using a magnetic resonance imaging (MRI) system, A pulse sequence that is originally design...
Differential efficiency of transcutaneous electrical nerve stimulation in dominant versus nondominant hands in fibromyalgia: placebo-controlled functional near-infrared spectroscopy study
EKEN, AYKUT; KARA, MURAT; BASKAK, BORA; Baltaci, Aysegul; Gökçay, Didem (2018-01-01)
Using functional near-infrared spectroscopy (fNIRS), modulation of hemodynamic responses by transcutaneous electrical nerve stimulation (TENS) during delivery of nociceptive stimulation was investigated in fibromyalgia (FM) patients and healthy controls for both hands. Two experiments were conducted: (1) median nerve stimulation with TENS and (2) painful stimulation using electronic von Frey filaments with TENS/placebo TENS. Mean Delta HbO(2) brain activity was compared across groups and conditions using fa...
Quantification of the Effects of Transcutaneous Electrical Nerve Stimulation With Functional Magnetic Resonance Imaging: A Double-Blind Randomized Placebo-Controlled Study
KARA, MURAT; ÖZÇAKAR, LEVENT; Gökçay, Didem; ÖZÇELİK, EROL; Yorubulut, Mehmet; Guneri, Sinem; KAYMAK, BAYRAM; AKINCI, AYŞEN; ÇETİN, ALP (Elsevier BV, 2010-08-01)
Objective: To evaluate the effects of transcutaneous electric nerve stimulation (TENS) by using functional magnetic resonance imaging (fMRI) in patients with carpal tunnel syndrome (CTS).
Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease
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Previous research suggests that oscillatory coupling between cortex, basal ganglia and muscles plays an important role in motor behavior. Furthermore, there is evidence that oscillatory coupling is altered in patients with movement disorders such as Parkinson's disease (PD).
Assessment of effects of multi drug resistance on dielectric properties of K562 leukemic cells using electrorotation
Bahrieh, Garsha; Erdem, Murat; Ozgur, Ebru; Gündüz, Ufuk; Külah, Haluk (2014-01-01)
In this study, dielectric characterization of multidrug resistant (MDR) K562 human leukemia cells was carried out using a MEMS based electrorotation (ER) device with 3D electrodes. P-glycoprotein (P-gp) dependent MDR causes variation in cell dielectric properties (cell interior conductivity (sigma(i)), membrane capacitance (C-m) and total effective membrane conductance (G(m)*)) due to overexpression of P-gp, which modulates the activity of membrane-bound Cl- channels. Different cell populations resistant to...
Citation Formats
A. Eken, “Investigating pain perception in somatosensory cortex for healthy and fibromyalgia patient populations by using fNIRS,” Ph.D. - Doctoral Program, Middle East Technical University, 2016.