Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Investigating pain perception in somatosensory cortex for healthy and fibromyalgia patient populations by using fNIRS
Download
index.pdf
Date
2016
Author
Eken, Aykut
Metadata
Show full item record
Item Usage Stats
350
views
161
downloads
Cite This
In this study, we investigated the difference in hemodynamic responses between fibromyalgia (FM) and healthy controls via functional near infrared spectroscopy (fNIRS) during application of painful stimulus and transcutaneous electrical nerve stimulation (TENS). We collected several clinical data (pain threshold, Beck Depression Inventory (BDI) score, Fibromyalgia Impact Questionnaire (FIQ) score, pain ratings) before and during the experiment. After data collection, we analyzed it using general linear model (GLM) and we applied classification methods to determine which cortical structures are important in discriminating healthy and patient groups. Our study showed that TENS effect was observed in both hands of healthy controls, but only left hand of FM patients. However, there is an opposite effect observed when the right hand of FM patients is stimulated. These findings indicate that the pain perception mechanism in FM syndrome needs further investigation since the outcome of the TENS treatment differs with respect to hands. When classification is done using SVM using features from the painful stimulation experiment, an accuracy of %90 is observed in distinguishing patients from healthy controls.
Subject Keywords
Fibromyalgia.
,
Inflammation.
,
Rheumatology.
,
Somatosensory cortex.
,
Magnetic resonance imaging.
URI
http://etd.lib.metu.edu.tr/upload/12620606/index.pdf
https://hdl.handle.net/11511/26142
Collections
Graduate School of Informatics, Thesis
Suggestions
OpenMETU
Core
Measurement of AC magnetic field distribution using magnetic resonance imaging
Ider, YZ; Muftuler, LT (1997-10-01)
Electric currents are applied to body in numerous applications in medicine such as electrical impedance tomography, cardiac defibrillation, electrocautery, and physiotherapy. If the magnetic field within a region is measured, the currents generating these fields can be calculated using the curl operator. In this study, magnetic fields generated within a phantom by currents passing through an external wire is measured using a magnetic resonance imaging (MRI) system, A pulse sequence that is originally design...
Differential efficiency of transcutaneous electrical nerve stimulation in dominant versus nondominant hands in fibromyalgia: placebo-controlled functional near-infrared spectroscopy study
EKEN, AYKUT; KARA, MURAT; BASKAK, BORA; Baltaci, Aysegul; Gökçay, Didem (2018-01-01)
Using functional near-infrared spectroscopy (fNIRS), modulation of hemodynamic responses by transcutaneous electrical nerve stimulation (TENS) during delivery of nociceptive stimulation was investigated in fibromyalgia (FM) patients and healthy controls for both hands. Two experiments were conducted: (1) median nerve stimulation with TENS and (2) painful stimulation using electronic von Frey filaments with TENS/placebo TENS. Mean Delta HbO(2) brain activity was compared across groups and conditions using fa...
Quantification of the Effects of Transcutaneous Electrical Nerve Stimulation With Functional Magnetic Resonance Imaging: A Double-Blind Randomized Placebo-Controlled Study
KARA, MURAT; ÖZÇAKAR, LEVENT; Gökçay, Didem; ÖZÇELİK, EROL; Yorubulut, Mehmet; Guneri, Sinem; KAYMAK, BAYRAM; AKINCI, AYŞEN; ÇETİN, ALP (Elsevier BV, 2010-08-01)
Objective: To evaluate the effects of transcutaneous electric nerve stimulation (TENS) by using functional magnetic resonance imaging (fMRI) in patients with carpal tunnel syndrome (CTS).
Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease
Hirschmann, J.; Özkurt, Tolga Esat; Butz, M.; Homburger, M.; Elben, S.; Hartmann, C. J.; Vesper, J.; Wojtecki, L.; Schnitzler, A. (2013-03-01)
Previous research suggests that oscillatory coupling between cortex, basal ganglia and muscles plays an important role in motor behavior. Furthermore, there is evidence that oscillatory coupling is altered in patients with movement disorders such as Parkinson's disease (PD).
Investigation of the fluidity of biological fluids with a PDDTBN spin probe
Severcan, Feride; Acar, B; Gokalp, S (1997-06-01)
The aim of this study is to ascertain whether the electron spin resonance technique using perdeutero-di-t-butyl nitroxide (PDDTBN) as a spin probe is able to monitor relative fluidity changes occurring in body fluids, such as blood and parotid saliva, according to different physiological conditions. The present study reveals that the spin probe PDDTBN is able to monitor the fluidity changes in parotid saliva related to habitual smoking, and in whole blood related to the estradiol level. The rotational corre...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
A. Eken, “Investigating pain perception in somatosensory cortex for healthy and fibromyalgia patient populations by using fNIRS,” Ph.D. - Doctoral Program, Middle East Technical University, 2016.