Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Date

2014-01-01

Author

Ozek, Nihal Simsek
Bal, I. Burak
SARA, MEHMET YILDIRIM
Onur, Rustu
Severcan, Feride

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.

Subject Keywords

Biophysics, Biochemistry, Molecular Biology

URI

https://hdl.handle.net/11511/57093

Collections

Department of Biology, Article