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Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles
Date
2014-01-01
Author
Ozek, Nihal Simsek
Bal, I. Burak
SARA, MEHMET YILDIRIM
Onur, Rustu
Severcan, Feride
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.
Subject Keywords
Biophysics
,
Biochemistry
,
Molecular Biology
URI
https://hdl.handle.net/11511/57093
Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
DOI
https://doi.org/10.1016/j.bbagen.2013.09.010
Collections
Department of Biology, Article