Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Ozek, Nihal Simsek
Bal, I. Burak
Onur, Rustu
Severcan, Feride
Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.