Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Ozek, Nihal Simsek
Bal, I. Burak
Onur, Rustu
Severcan, Feride
Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.


Modulation of human flavin-containing monooxygenase 3 activity by tricyclic antidepressants and other agents: Importance of residue 428
Adalı, Orhan; Philpot, RM (Elsevier BV, 1998-10-01)
Human flavin-containing monooxygenase 3 (FMO3) is subject to modulation by tricyclic antidepressants and other agents. Imipramine activates FMO3-catalyzed metabolism of methimazole at all substrate concentrations tested. This distinguishes FMO3 from rabbit FMO1 and FMO2, which are activated at high substrate concentration and inhibited at low substrate concentration, and pig FMO1, which is inhibited at all substrate concentrations. The response of FMO3 is also unique in that chlorpromazine is markedly more ...
Low dose simvastatin induces compositional, structural and dynamic changes in rat skeletal extensor digitorum longus muscle tissue
Ozek Simsek, Nihal; Sara, Yildirim; Onur, Rustu; Severcan, Feride (Portland Press Ltd., 2009-10-6)
<jats:p>Statins are commonly used drugs in the treatment of hypercholesterolaemia. There are many adverse effects of statins on skeletal muscle, but the underlying mechanisms remain unclear. In the present study, the effects of low dose (20 mg/kg) simvastatin, a lipophilic statin, on rat EDL muscle (extensor digitorum longus muscle) were investigated at the molecular level using FTIR (Fourier-transform infrared) spectroscopy. FTIR spectroscopy allows us rapid and sensitive determination of functional groups...
Interaction of the cholesterol reducing agent simvastatin with zwitterionic DPPC and charged DPPG phospholipid membranes
Sariisik, Ediz; KOÇAK, MUSTAFA; Baloglu, Fatma Kucuk; Severcan, Feride (Elsevier BV, 2019-04-01)
Simvastatin is a lipid-lowering drug in the pharmaceutical group statins. Interaction of a drug with lipids may define its role in the system and be critical for its pharmacological activity. We examined the interactions of simvastatin with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) and anionic dipalmitoyl phosphatidylglycerol (DPPG) multilamellar vesicles (MLVs) as a function of temperature at different simvastatin concentrations using Fourier transform infrared (FTIR) spectroscopy and differentia...
Structural and functional effects of non-steroidal anti-inflammatory drugs rofecoxib and valdecoxib on DSPC model membranes
Rachkauska, Richardas; Banerjee, Sreeparna; Severcan, Feride; Department of Biology (2014)
Celecoxib (CLX), rofecoxib (RFX) and valdecoxib (VLX) belong to a family of Non-steroidal anti-inflammatory drugs (NSAIDs), which are selective COX-2 inhibitors. While these drugs are established analgesics, they also have a number of pleiotropic effects such as cancer chemoprevention, occasionally in a COX-2 independent manner. RFX and VLX were withdrawn from the market after clinical trials indicated that use of these drugs enhanced the risk of heart attack and stroke. CLX is currently FDA approved for pa...
Gene expressions of Mn-SOD and GPx-1 in streptozotocin-induced diabetes: effect of antioxidants
Sadi, Goekhan; Güray, Nülüfer Tülün (Springer Science and Business Media LLC, 2009-07-01)
Increased oxidative stress and impaired antioxidant defense mechanisms are believed to be the important factors contributing to the pathogenesis and progression of diabetes mellitus. In this study, we have reported the effects of the streptozotocin-induced diabetes on the gene expression and the activities of two antioxidant enzymes, manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). We also studied the effects of two antioxidants, vitamin C and DL-alpha-lipoic acid (LA), on the system...
Citation Formats
N. S. Ozek, I. B. Bal, M. Y. SARA, R. Onur, and F. Severcan, “Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles,” BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, pp. 406–415, 2014, Accessed: 00, 2020. [Online]. Available: