Show/Hide Menu
Hide/Show Apps
anonymousUser
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Videos
Videos
Thesis submission
Thesis submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Contact us
Contact us
Chronic hypoperfusion alters the content and structure of proteins and lipids of rat brain homogenates: a Fourier transform infrared spectroscopy study
Date
2004-10-01
Author
Toyran, N
Zorlu, F
Donmez, G
Oge, K
Severcan, Feride
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
6
views
0
downloads
Cite This
Arteriovenous malformations (AVMs), masses of abnormal blood vessels which grow in the brain, produce high flow shunts that steal blood from surrounding brain tissue, which is chronically hypoperfused. Hypoperfusion is a condition of inadequate tissue perfusion and oxygenation, resulting in abnormal tissue metabolism. Fourier transform infrared (FTIR) spectroscopy is used in this study to investigate the effect of hypoperfusion on homogenized rat brain samples at the molecular level. The results suggest that the lipid content increases, the protein content decreases, the lipid-to-protein ratio increases, and the state of order of the lipids increases in the hypoperfused brain samples. FTIR results also revealed that, owing to hypoperfusion, not only the protein synthesis but also the protein secondary structure profile is altered in favor of beta-sheets and random coils. These findings clearly demonstrate that, FTIR spectroscopy can be used to extract valuable information at the molecular level so as to have a better understanding of the effect of hypoperfusion on rat brain.
Subject Keywords
Brain
,
Hypoperfusion
,
Macromolecules
,
Secondary structure
,
Fourier transform infrared spectroscopy
URI
https://hdl.handle.net/11511/57497
Journal
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
DOI
https://doi.org/10.1007/s00249-004-0396-1
Collections
Department of Biology, Article
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
N. Toyran, F. Zorlu, G. Donmez, K. Oge, and F. Severcan, “Chronic hypoperfusion alters the content and structure of proteins and lipids of rat brain homogenates: a Fourier transform infrared spectroscopy study,”
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
, vol. 33, no. 6, pp. 549–554, 2004, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57497.