Self-assembly of organocatalysts for the enantioselective Michael addition of aldehydes to nitroalkenes

2010-01-29
Demir, Ayhan Sıtkı
Eymur, Serkan
A proline-thiourea self-assembled organocatalyst is described as a good catalyst for the enantioselective nitro-Michael addition of aldehydes to nitroalkenes The reaction is efficient with 5% of the thiourea, to give moderate to good enantioselectivity (up to 76% ee) High syn-selectivity was obtained with both branched and unbranched aliphatic aldehydes This is the first example of self-assembly of organocatalysts with an achiral additive in a Michael addition wherein aldehydes are utilized as donors. (c) 2009 Elsevier Ltd All rights reserved

Citation Formats
A. S. Demir and S. Eymur, “Self-assembly of organocatalysts for the enantioselective Michael addition of aldehydes to nitroalkenes,” TETRAHEDRON-ASYMMETRY, vol. 21, no. 1, pp. 112–115, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62588.