Theoretical aspects of some 4-[2,6-substituted-9H-purin-9-yl]-2-cyclopentene-1-methanol derivatives as anti-HIV agents

2000-01-01
Türker, Burhan Lemi
Sudagidan, M
Some (-)-(1S,4R) -4-[2-amino-6-(substituted)-9H-purin-9-yl]-2-cyclopentene-1-methanol derivatives have been considered for semiempirical treatment at the level of AM1 type calculations. Certain theoretical structure-activity relationship were investigated.
ACH-MODELS IN CHEMISTRY

Suggestions

Reaction of pentacarbonyl(eta(2)-bis(trimethylsilyl)ethyne)tungsten(0) with tricyclohexylphosphine: X-ray structure of pentacarbonyltricyclohexylphosphinetungsten(0)
Demircan, O; Özkar, Saim; Ulku, D; Yildirim, LT (2003-12-15)
The pentacarbonyl(?(2)-bis(trimethylsilyl)ethyne)tungsten(0), W(CO)(5)(?(2)-btmse), reacts with tricyclohexylphosphine, PCy3, to yield two stable endproducts which could be isolated and fully characterized by using the single crystal X-ray diffractometry and the MS, IR, and NMR spectroscopy: W(CO)(5)(PCy3) and trans-W(CO)(4)(PCy3)(2). The former complex is the alkyne substitution product, while the latter one is formed from the conversion of its labile cis-isomer, which is generated by further reaction of t...
Challenges in line-of-balance scheduling
Arditi, David; Tokdemir, Onur Behzat; Suh, Kangsuk (American Society of Civil Engineers (ASCE), 2002-11-01)
The line-of-balance ~LOB! method of scheduling is well suited to projects that are composed of activities of a linear and repetitive nature. The objective of this study is to set down the basic principles that can be used in the development of a computerized LOB scheduling system that overcomes the problems associated with existing systems and creates solutions to problems encountered in the implementation of repetitive-unit construction. The challenges associated with LOB scheduling include developing an a...
A new and stereospecific synthesis of an inositol analogue: bis-homoinositol
Kara, Y; Balcı, Metin (2003-03-17)
The photooxygenation of trans-8-(acetyloxy)bicyclo[4.2.0]octa-2,4-dien-7-yl acetate afforded the bicyclic endoperoxide. Reduction of the endoperoxide with thiourea followed by acetylation gave the corresponding tetraacetate. The KMnO4 oxidation of the tetraacetate followed by acetylation gave dihydroxytetraacetate Ammonolysis of tetraacetate afforded the bis-homoinositol, bicyclo[4.2.0]octane-2,3,4,5,7,8-hexol.
A new antiaromatic compound: 1,4-biphenylenequinone synthesis and trapping reactions: can a quinone unit stabilize the cyclobutadiene?
Kilic, H; Balcı, Metin (2001-12-03)
The photooxygenation of 4a,8b-dihydrobiphenylene affords an endoperoxide. NEt3-catalyzed rearrangement of this endoperoxide gave the corresponding hydroxy enone, while the CoTPP-catalyzed rearrangement afforded a bisepoxide. MnO2 oxidation of hydroxy enol leads to 4a,8b-dihydrobiphenylene-1,4-dione. The NIBS bromination of this dione produces mono- and dibromides. NEt3-supported elimination of monobromide and zinc elimination of dibromide afforded the target compound, 1,4-biphenylenequinone, which was trapp...
A stable carbonyl-pyrazine-metal(0) complex: Synthesis and characterization of cis-tetracarbonylpyrazinetrimethylphosphitetungsten(0)
Alper, Fatma; Kayran, Ceyhan; Özkar, Saim (2006-06-01)
Pentacarbonylpyrazinetungsten(0), (CO)(5)W(pyz), is not stable in solution in polar solvents such as acetone or dichloromethane and undergoes conversion to a bimetallic complex, (CO)(5)W(pyz)W(CO)(5) plus free pyrazine. These three species exist at equilibrium. Using the quantitative H-1 NMR spectroscopy, the equilibrium constant could be determined to be K-eq = (5.9 +/- 0.8) x 10(-2) at 25 degrees C. Introducing a second pyrazine ligand into the molecule does not stabilize the complex, as CiS-W(CO)(4)(pyz)...
Citation Formats
B. L. Türker and M. Sudagidan, “Theoretical aspects of some 4-[2,6-substituted-9H-purin-9-yl]-2-cyclopentene-1-methanol derivatives as anti-HIV agents,” ACH-MODELS IN CHEMISTRY, pp. 49–56, 2000, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62672.