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Benzaldehyde Lyase-Catalyzed Direct Amidation of Aldehydes with Nitroso Compounds
Date
2011-03-07
Author
Ayhan, Peruze
Demir, Ayhan Sıtkı
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Benzaldehyde lyase from the Pseudomonas fluorescens catalyzes the reaction of aromatic aldehydes with nitroso compounds and furnishes N-arylhydroxamic acids in high yields. Aromatic aldehydes and benzoins are converted into enamine-carbanion-like intermediates prior to their reaction with nitroso compounds. The kinetic resolution of rac-2-hydroxy-1,2-diphenylethanones furnished (S)-benzoins and arylhydroxamic acids with high enantioselectivities and conversions.
Subject Keywords
Organic Chemistry
,
Catalysis
URI
https://hdl.handle.net/11511/62710
Journal
ADVANCED SYNTHESIS & CATALYSIS
DOI
https://doi.org/10.1002/adsc.201000735
Collections
Department of Chemistry, Article
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P. Ayhan and A. S. Demir, “Benzaldehyde Lyase-Catalyzed Direct Amidation of Aldehydes with Nitroso Compounds,”
ADVANCED SYNTHESIS & CATALYSIS
, pp. 624–629, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62710.