Benzaldehyde Lyase-Catalyzed Direct Amidation of Aldehydes with Nitroso Compounds

Date

2011-03-07

Author

Ayhan, Peruze
Demir, Ayhan Sıtkı

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Benzaldehyde lyase from the Pseudomonas fluorescens catalyzes the reaction of aromatic aldehydes with nitroso compounds and furnishes N-arylhydroxamic acids in high yields. Aromatic aldehydes and benzoins are converted into enamine-carbanion-like intermediates prior to their reaction with nitroso compounds. The kinetic resolution of rac-2-hydroxy-1,2-diphenylethanones furnished (S)-benzoins and arylhydroxamic acids with high enantioselectivities and conversions.

Subject Keywords

Organic Chemistry, Catalysis

URI

https://hdl.handle.net/11511/62710

Journal

ADVANCED SYNTHESIS & CATALYSIS

DOI

https://doi.org/10.1002/adsc.201000735

Collections

Department of Chemistry, Article

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Citation Formats

P. Ayhan and A. S. Demir, “Benzaldehyde Lyase-Catalyzed Direct Amidation of Aldehydes with Nitroso Compounds,” ADVANCED SYNTHESIS & CATALYSIS, pp. 624–629, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62710.