Benzaldehyde Lyase-Catalyzed Direct Amidation of Aldehydes with Nitroso Compounds

2011-03-07
Ayhan, Peruze
Demir, Ayhan Sıtkı
Benzaldehyde lyase from the Pseudomonas fluorescens catalyzes the reaction of aromatic aldehydes with nitroso compounds and furnishes N-arylhydroxamic acids in high yields. Aromatic aldehydes and benzoins are converted into enamine-carbanion-like intermediates prior to their reaction with nitroso compounds. The kinetic resolution of rac-2-hydroxy-1,2-diphenylethanones furnished (S)-benzoins and arylhydroxamic acids with high enantioselectivities and conversions.
ADVANCED SYNTHESIS & CATALYSIS

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Citation Formats
P. Ayhan and A. S. Demir, “Benzaldehyde Lyase-Catalyzed Direct Amidation of Aldehydes with Nitroso Compounds,” ADVANCED SYNTHESIS & CATALYSIS, pp. 624–629, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62710.