Mesenchymal Stem Cells and Nano-Bioceramics for Bone Regeneration

Kankilic, Berna
Kose, Sevil
Timucin, Muharrem
Korkusuz, Feza
Orthopedic disorders and trauma usually result in bone loss. Bone grafts are widely used to replace this tissue. Bone grafts excluding autografts unfortunately have disadvantages like evoking immune response, contamination and rejection. Autografts are of limited sources and optimum biomaterials that can replace bone have been searched for several decades. Bioceramics, which have the similar inorganic structure of natural bone, are widely used to regenerate bone or coat metallic implants. As people continuously look for a higher life quality, there are developments in technology almost everyday to meet their expectations. Nanotechnology is one of such technologies and it attracts everyone's attention in biomaterial science. Nano scale biomaterials have many advantages like larger surface area and higher biocompatibility and these properties make them more preferable than micro scale. Also, stem cells are used for bone regeneration besides nano-bioceramics due to their differentiation characteristics. This review covers current research on nano-bioceramics and mesenchymal stem cells and their role in bone regeneration.


Biological Responses of Ceramic Bone Spacers Produced by Green Processing of Additively Manufactured Thin Meshes
Minguella-Canela, Joaquim; Calero, Jose Antonio; Korkusuz, Feza; Korkusuz, Petek; Kankılıç, Berna; Bilgiç, Elif; De los Santos-López, M. Antonia (MDPI AG, 2020-5-30)
Bone spacers are exclusively used for replacing the tissue after trauma and/or diseases. Ceramic materials bring positive opportunities to enhance greater osteointegration and performance of implants, yet processing of porous geometries can be challenging. Additive Manufacturing (AM) opens opportunities to grade porosity levels in a part; however, its productivity may be low due to its batch processing approach. The paper studies the biological responses yielded by hydroxyapatite with beta -TCP (tricalcium ...
Tenogenic differentiation of human adipose derived MSCS on a novel tendon scaffold by gdf-5 supplementation
Güner, Mustafa Bahadır; Keskin, Dilek; Yılancı, Sedat; Department of Biomedical Engineering (2018)
Tendon injuries are a significant part of musculoskeletal wounds. Even though tendon wound healing mechanisms provide regeneration after injuries, reduced function of the tendon usually occurs due to limitations of the native healing mechanism. Tendon tissue engineering (TTE) is proposed to repair the injured tendon by a scaffold integrated with biological factors. Therefore, aim of this thesis was to design 3D scaffold, by combining healthy and wounded extracellular matrix (ECM) structure of the tendon, to...
Multiwalled Carbon Nanotube- Poly(2-Hydroxyethyl Methacrylate) Composite Conduitfor Peripheral Nerve Repair
Arslantunalı, Damla; Arslantunalı Şahin, Damla; Department of Biotechnology (2012)
There are different methods used in the surgical treatment of peripheral nerve injury. In this respect, end-to-end surgical reconnection of the damaged nerve ends or autologous nerve grafts are applied as soon as possible after the injury. When autologous tissue transplant is considered, there are some medical devices available generally for relatively short nerve defects. As a solution for this problem, different tissue engineered nerve conduits have been developed. In the current study, a pHEMA hydrogel m...
Tissue Engineered, Guided Nerve Tube Consisting of Aligned Neural Stem Cells and Astrocytes
Yucel, Deniz; Kose, Gamze Torun; Hasırcı, Vasıf Nejat (2010-12-01)
Injury of the nervous system, particularly in the spinal cord, impairs the quality of life of the patient by resulting in permanent loss of neurologic function. The main limitation in spinal cord regeneration is the lack of extracellular matrix to guide nerves for functional recovery of the transected nerve tissue. In the present study, a tissue engineered nerve tube was prepared by wrapping neural stem cells (NSCs) on aligned fibers using a micropatterned film with astrocytes aligned along the microgrooves...
Etiology of senile osteoporosis - A hypothesis
Atik, O. Sahap; Uslu, M. Murad; Eksioglu, Fatih; Satana, Tolgay (Ovid Technologies (Wolters Kluwer Health), 2006-02-01)
Osteoporosis is a major health problem characterized by compromised bone strength predisposing patients to an increased risk of fracture. It may cause morbidity and mortality in elderly men and women. The etiologic factors that lead to senile osteoporosis still are unclear.
Citation Formats
B. Kankilic, S. Kose, P. KORKUSUZ, M. Timucin, and F. Korkusuz, “Mesenchymal Stem Cells and Nano-Bioceramics for Bone Regeneration,” CURRENT STEM CELL RESEARCH & THERAPY, pp. 487–493, 2016, Accessed: 00, 2020. [Online]. Available: