The synthesis and investigation of the antimicrobial activity of some new phenylselanyl-1-(toluene-4sulfonyl)-1H-tetrazole derivatives

Date

2009-03-01

Author

YILDIRIR, YILMAZ
Us, M. Faruk
Colak, Naki
Oezkan, Hamdi
YAVUZ, SERKAN
DİŞLİ, ALİ
Ozturk, Sahlan
Türker, Burhan Lemi

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The sulfonamide functional group has aroused interest in both medicinal and bioorganic chemistry. In this study, some new phenylselanyl-1-(toluene-4-sulfonyl)-1H-tetrazole derivatives (2a-f) have been synthesized using dicyclohexylcarbodiimide/dimethylaminopyridine (DCC/DMAP). The structures of the presently synthesized compounds were elucidated by spectroscopic methods [Fourier-transform infrared (FTIR) spectroscopy, (1)H nuclear magnetic resonance (NMR), (13)C nuclear magnetic resonance-attached proton test ((13)C NMR-APT), and mass spectrometry (MS)]. In addition, the antimicrobial activity of the synthesized compounds and two antibiotics [sulfamethoxazole (SMX) and sulfamerazine (SRZ)] were investigated against some microorganisms.

Subject Keywords

General Pharmacology, Toxicology and Pharmaceutics, Organic Chemistry

URI

https://hdl.handle.net/11511/63039

Journal

MEDICINAL CHEMISTRY RESEARCH

DOI

https://doi.org/10.1007/s00044-008-9110-7

Collections

Department of Chemistry, Article

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Citation Formats

Y. YILDIRIR et al., “The synthesis and investigation of the antimicrobial activity of some new phenylselanyl-1-(toluene-4sulfonyl)-1H-tetrazole derivatives,” MEDICINAL CHEMISTRY RESEARCH, pp. 91–97, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/63039.