Chronic intracerebroventricular NGF administration improves working memory in young adult memory deficient rats

Date

2005-07-01

Author

Jakubowska-Dogru, E
Gumusbas, U

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

184
views

0
downloads

Although the beneficial effects of nerve growth factor (NGF) in age-related memory deficits are well documented, the therapeutic role of this neurotrophin in memory deficits occurring in young Subjects remains unclear. In the present study, the effect of chronic NGF administration on spatial working memory was investigated in young adult memory deficient Wistar rats. Memory deficient rats were selected on the basis of their preoperative performance in delayed matching-to-position task (DMTP) carried out in the eight-arm radial maze. The delay between sample and test choices was prolonged stepwise from 10 s, to 1, 5, and eventually 15 min. Rats that performance at the longest 15-min delay was at least 3 S.E.M. above the group mean were classified as "poor learners". They were randomly assigned to either Control or NGF group, and treated with either vehicle solution (artificial cerebrospinal fluid) or NGF at the total dose of 40 mu g/rat. Intracerebroventricular (icv) drug infusion was made continuously over 28 days at the rate of 0.25 mu l/h using Alzet 2004 osmotic mini-pump. The postoperative training included the same stages as the preoperative one. No significant between-group difference in the postoperative performance was noted at the shortest delay of 10 s that could be bridged by the immediate memory. Conversely, at all three longer delays, postoperative performance in the NGF group was significantly better compared to control rats. The present study thus shows that NGF may have beneficial effects in memory-deficient young adults. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Subject Keywords

General Neuroscience

URI

https://hdl.handle.net/11511/64469

Journal

NEUROSCIENCE LETTERS

DOI

https://doi.org/10.1016/j.neulet.2005.02.059

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion SAYAN ÖZAÇMAK, HALE; SAYAN, Hale; BARUT, FİGEN; Jakubowska-Dogru, Ewa (Bentham Science Publishers Ltd., 2011-08-01) Chronic cerebral hypoperfusion can cause learning and memory impairment and neuronal damage resembling the effects observed in vascular dementia. PPAR-gamma agonists were shown to modulate inflammatory response and neuronal death following cerebral ischemia. The present study was designed to evaluate possible neuroprotective effects of rosiglitazone, a PPAR-gamma agonist, in rat model of chronic cerebral hypoperfusion. Cerebral hypoperfusion was induced by permanent bilateral occlusion of the common carotid...
Hippocampal levels of ChAT, PKA, phospho-PKA and phospho-CaMKII alpha but not CaMKII alpha positively correlate with spatial learning skills in rats Gokcek-Sarac, Cigdem; Adalı, Orhan; Jakubowska-Dogru, Ewa (Elsevier BV, 2013-06-17) Despite very extensive investigations on molecular processes underlying memory formation, there are very few studies examining potential differences in the brain biochemistry between "good" and "poor" learners belonging to a random population of young animals. In the present study, an attempt was made to correlate individual variation in spatial learning in young-adult Long-Evans rats with hippocampal levels of protein kinase A (PKA), calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha), and ...
Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus ELİBOL, BİRSEN; BEKER, MERVE; Sahbaz, Cigdern Dilek; Kilic, Ulkan; Jakubowska-Dogru, Ewa (Exeley, Inc., 2019-01-01) It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated. The aim of this study was to examine whether the postnatal attenuation of fetal alcohol - and maternal stress-induced morphological and functional deficits correlates with compensatory changes...
Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging Tuz-Sasik, Melek Umay; Karoglu-Eravsar, Elif Tugce; Kinali, Meric; ARSLAN ERGÜL, AYÇA; ADAMS, MİCHELLE (Elsevier BV, 2020-06-01) Aging occurs due to a combination of several factors, such as telomere attrition, cellular senescence, and stem cell exhaustion. The telomere attrition-dependent cellular senescence is regulated by increased levels of SMAD specific E3 ubiquitin protein ligase 2 (smurf2). With age smurf2 expression increases and Smurf2 protein interacts with several regulatory proteins including, Smad7, Ep300, Yy1, Sirt1, Mdm2, and Tp53, likely affecting its function related to cellular aging. The current study aimed at anal...
The effects of repeated antibiotic administration to juvenile BALB/c mice on the microbiota status and animal behavior at the adult age Ceylani, Taha; Jakubowska-Dogru, Ewa; Gurbanov, Rafig; Teker, Hikmet Taner; Gözen, Ayşe Gül (2018-06-01) Recent studies carried on germ -free (GF) animal models suggest that the gut microbiota (GM) may play a role in the regulation of anxiety, mood, and cognitive abilities such as memory and learning processes. Consistently, any treatment disturbing the gut microbiota, including the overuse of antibiotics, may influence the brain functions and impact behavior. In the present study, to address this issue, two wide-spectrum antibiotics (ampicillin and cefoperazone, 1 g/l) were repeatedly applied throughout a 6-w...

Citation Formats

E. Jakubowska-Dogru and U. Gumusbas, “Chronic intracerebroventricular NGF administration improves working memory in young adult memory deficient rats,” NEUROSCIENCE LETTERS, pp. 45–50, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/64469.