Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion

Jakubowska-Dogru, Ewa
Chronic cerebral hypoperfusion can cause learning and memory impairment and neuronal damage resembling the effects observed in vascular dementia. PPAR-gamma agonists were shown to modulate inflammatory response and neuronal death following cerebral ischemia. The present study was designed to evaluate possible neuroprotective effects of rosiglitazone, a PPAR-gamma agonist, in rat model of chronic cerebral hypoperfusion. Cerebral hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. Oral administration of rosiglitazone (1.5, 3, and 6 mg/kg/day) or vehicle was carried out for 5 weeks, starting one week before the surgery. Cognitive performance was assessed using the Morris water maze. The density of S100B protein-immunoreactive astrocytes and the OX-42-labeled microglial activation were estimated. Synaptogenesis was also evaluated by the measurement of synaptophysin, the pre-synaptic vesicular protein, level via western blotting technique.


Chronic intracerebroventricular NGF administration improves working memory in young adult memory deficient rats
Jakubowska-Dogru, E; Gumusbas, U (Elsevier BV, 2005-07-01)
Although the beneficial effects of nerve growth factor (NGF) in age-related memory deficits are well documented, the therapeutic role of this neurotrophin in memory deficits occurring in young Subjects remains unclear. In the present study, the effect of chronic NGF administration on spatial working memory was investigated in young adult memory deficient Wistar rats. Memory deficient rats were selected on the basis of their preoperative performance in delayed matching-to-position task (DMTP) carried out in ...
Hippocampal levels of ChAT, PKA, phospho-PKA and phospho-CaMKII alpha but not CaMKII alpha positively correlate with spatial learning skills in rats
Gokcek-Sarac, Cigdem; Adalı, Orhan; Jakubowska-Dogru, Ewa (Elsevier BV, 2013-06-17)
Despite very extensive investigations on molecular processes underlying memory formation, there are very few studies examining potential differences in the brain biochemistry between "good" and "poor" learners belonging to a random population of young animals. In the present study, an attempt was made to correlate individual variation in spatial learning in young-adult Long-Evans rats with hippocampal levels of protein kinase A (PKA), calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha), and ...
Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus
ELİBOL, BİRSEN; BEKER, MERVE; Sahbaz, Cigdern Dilek; Kilic, Ulkan; Jakubowska-Dogru, Ewa (Exeley, Inc., 2019-01-01)
It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated. The aim of this study was to examine whether the postnatal attenuation of fetal alcohol - and maternal stress-induced morphological and functional deficits correlates with compensatory changes...
Phase validation of neurotoxic animal models of Parkinson's disease
Telkes, İlknur; Jakubowska Doğru, Ewa; Department of Medical Informatics (2012)
Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic nigral neurons and striatal dopamine resulting in serious motor deficits but also some non-motor anomalies. Animal models of human neurodegenerative diseases are essential for better understanding their pathogenesis and developing efficient therapeutic tools. There are many different PD models, however, none of them is fully reproducing all the symptoms of the disease. In addition, different investigators use different behavio...
Hierarchical multi-resolution mesh networks for brain decoding
Ertugrul, Itir Onal; Ozay, Mete; Yarman Vural, Fatoş Tunay (Springer Science and Business Media LLC, 2018-08-01)
Human brain is supposed to process information in multiple frequency bands. Therefore, we can extract diverse information from functional Magnetic Resonance Imaging (fMRI) data by processing it at multiple resolutions. We propose a framework, called Hierarchical Multi-resolution Mesh Networks (HMMNs), which establishes a set of brain networks at multiple resolutions of fMRI signal to represent the underlying cognitive process. Our framework, first, decomposes the fMRI signal into various frequency subbands ...
Citation Formats
H. SAYAN ÖZAÇMAK, H. SAYAN, F. BARUT, and E. Jakubowska-Dogru, “Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion,” CURRENT NEUROVASCULAR RESEARCH, pp. 190–199, 2011, Accessed: 00, 2020. [Online]. Available: