Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion

Date

2011-08-01

Author

SAYAN ÖZAÇMAK, HALE
SAYAN, Hale
BARUT, FİGEN
Jakubowska-Dogru, Ewa

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Chronic cerebral hypoperfusion can cause learning and memory impairment and neuronal damage resembling the effects observed in vascular dementia. PPAR-gamma agonists were shown to modulate inflammatory response and neuronal death following cerebral ischemia. The present study was designed to evaluate possible neuroprotective effects of rosiglitazone, a PPAR-gamma agonist, in rat model of chronic cerebral hypoperfusion. Cerebral hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. Oral administration of rosiglitazone (1.5, 3, and 6 mg/kg/day) or vehicle was carried out for 5 weeks, starting one week before the surgery. Cognitive performance was assessed using the Morris water maze. The density of S100B protein-immunoreactive astrocytes and the OX-42-labeled microglial activation were estimated. Synaptogenesis was also evaluated by the measurement of synaptophysin, the pre-synaptic vesicular protein, level via western blotting technique.

Subject Keywords

Developmental Neuroscience, Cellular and Molecular Neuroscience, Neurology

URI

https://hdl.handle.net/11511/67729

Journal

CURRENT NEUROVASCULAR RESEARCH

DOI

https://doi.org/10.2174/156720211796558087

Collections

Department of Biology, Article

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Citation Formats

H. SAYAN ÖZAÇMAK, H. SAYAN, F. BARUT, and E. Jakubowska-Dogru, “Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion,” CURRENT NEUROVASCULAR RESEARCH, pp. 190–199, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67729.