The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of ankylosing spondylitis, behcet disease, sarcoidosis and latent tuberculosis

Date

2013-06-01

Author

Gurses, Ozlem
Karaismailoglu, Eda

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

230
views

0
downloads

Purpose: To evaluate the significance of differences in serum angiotensin converting enzyme and lysozyme levels between the patient groups. Methods: This is a prospective study involving 37 patients with HLAB27+ ankylosing spondylitis, 47 patients with HLAB51+ behcet disease, 29 patients with sarcoidosis and 27 patients with quantiferon+ latent tuberculosis. The patients are included in the study according to the tenets of Decleration of Helsinki. The serum levels of angiotensin converting enzyme and lysozyme are analyzed by enzyme-linked immunosorbent assay. Krusal Wallis and Mann Whitney U tests are used for age distribution, and Chi Square test is used for sex distribution. Multivariate analysis of covariance is used to analyze the significance of differences in serum levels of angiotensin converting enzyme and lysozyme between the patient groups.Results: The increase in serum angiotensin converting enzyme level is significant for patients with sarcoidosis with respect to HLAB27+ankylosing spondylitis, (p<0.001) HLAB51+ behcet disease, (p<0.001) and quantiferon+ latent tuberculosis. (p=0.015) The increase in serum lysozyme level is significant for patients with sarcoidosis with respect to HLAB27+ ankylosing spondylitis,( p< 0.001) and HLAB51+ behcet disease. (p<0.001) However, there is no significant difference of increase serum lysozyme levels between patients with sarcoidosis and quantiferon+ latent tuberculosis. (p=0.051) Conclusions: The increase in serum angiotensin converting enzyme level is helpful for the diagnosis of sarcoidosis. The increase in serum lysozyme level is considered to be helpful for the diagnosis of both sarcoidosis and quantiferon+ latent tuberculosis.

Subject Keywords

459 Clinical (Human) Or Epidemiologic Studies: Biostatistics/Epidemiology Methodology , 514 Enzymes/Enzyme Inhibitors , 746 Uveitis-Clinical/Animal Model

URI

https://hdl.handle.net/11511/66080

Journal

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Collections

Unclassified, Article

Suggestions

OpenMETU
Core

The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of autoimmune and infectious diseases Sahin, Ozlem; Ziaei, Alireza; Karaismailoğlu, Eda; Taheri, Nusret (Springer Science and Business Media LLC, 2016-2-16) Background: Increased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. The purpose of this study is to evaluate the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases. Methods: This is a prospective study involving patients with ankylosing spondylitis, behc...
Increased Serum Interleukin-23 Levels In Patients With Behcet Disease-Associated Uveitis Gurses, Ozlem; Koc, Elcin Kartal (2014-04-01) Purpose: The aim of this study is to compare the serum interleukin (IL) levels between the patients with extraocular manifestations of Behçet disease and Behçet disease-associated uveitis. Methods: This is a prospective study involving 12 patients with extraocular manifestations of Behçet disease and 16 patients with Behçet disease-associated uveitis. The patients are involved in this study according to declaration of Helsinki. Inclusion criteria for all patients consist of a positive HLA B51 tissue typing...
The effects of insertional mutations in comQ, comP, srfA, spo0H, spo0A and abrB genes on bacilysin biosynthesis in Bacillus subtilis Karatas, AY; Cetin, S; Özcengiz, Gülay (Elsevier BV, 2003-04-15) In Bacillus subtilis, two extracellular signaling peptides, ComX pheromone and CSF (competence and sporulation factor), stimulate the development of genetic competence and surfaction biosynthesis in response to high cell density (quorum sensing) by regulating the activity of transcription factor ComA. We recently showed that biosynthesis of dipeptide antibiotic bacilysin is linked to ComA and PhrC(CSF) in a Spo0K(Opp)-dependent manner by constructing phrC-, comA- and oppA-disrupted mutants of B. subtilis. I...
The effect of sustained and local administration of epidermal growth factor on improving bilateral testicular tissue after torsion Uguralp, S; Karabulut, AB; Mizrak, B; Kaymaz, F; Kiziltay, A; Hasırcı, Nesrin (2004-10-01) Epidermal growth factor (EGF) modulates Leydig cell proliferation, steroidogenesis, spermiogenesis, and Sertoli cell activity. It plays an important role in repairing ischemia-reperfusion injury in different tissues. The aim of this study was to evaluate the effects of sustained and local administration of EGF on improving bilateral testicular tissue after torsion. A total of 57 Wistar albino rats were used. For the EGF transport system, 1x2 cm gelatin films containing 2 mug EGF were used. Torsion was creat...
Solid-phase enzyme modification via affinity chromatography Baran, ET; Ozer, N; Hasırcı, Vasıf Nejat (2003-09-05) In the present study antileukemic enzyme L-asparaginase (ASNase) and catalase (as a model enzyme) were modified in solid-phase with activated polyethylene glycol (PEG,) by using ligand-immobilized affinity column systems L-asparagine-Sepharose CL-4B and Procion red-Sepharose CL-4B, respectively. Studies on change of specific activity with modification time showed negligible differences between batches of modified catalase. Modification of ASNase for I It resulted in 50.2% recovery of the specific activity a...

Citation Formats

O. Gurses and E. Karaismailoglu, “The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of ankylosing spondylitis, behcet disease, sarcoidosis and latent tuberculosis,” INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, pp. 0–0, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/66080.